Results 61 to 70 of about 10,024,591 (280)

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy

Advanced Science, EarlyView.
Awake longitudinal multimodal ultrasound imaging integrates functional ultrasound (fUS), ultrasound localization microscopy (ULM), and functional ULM (fULM) to characterize cerebrovascular function, microvascular architecture, and flow dynamics within the same animals over time.
Zhe Huang, Yike Wang, Matthew R. Lowerison, Yue Xu, Murong Yi, Bing‐Ze Lin, YiRang Shin, Nathiya Vaithiyalingam Chandra Sekaran, Daniel A. Llano, Pengfei Song   +9 more
wiley   +1 more source

Neutrophil-to-lymphocyte ratio associated with an increased risk of mortality in patients with critical limb ischemia.

PLoS ONE, 2021
PurposeAssociation of the neutrophil-to-lymphocyte ratio (NLR) with mortality has not been comprehensively explored in critical limb ischemia (CLI) patients.
Min-I Su, Cheng-Wei Liu
doaj   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Impact of high on-treatment platelet reactivity after angioplasty in patients with peripheral arterial disease

Platelets, 2021
Objective: High on-treatment platelet reactivity (HTPR) to dual antiplatelet therapy (DAPT) predicts adverse events in coronary artery disease patients. In peripheral artery disease (PAD) patients, data concerning the clinical impact of HTPR are limited.
Lucas Busch, Manuel Stern, Lisa Dannenberg, Philipp Mourikis, Michael Gröne, Göksen Özaslan, Yvonne Heinen, Christian Heiss, Roberto Sansone, Amin Polzin, Malte Kelm   +10 more
doaj   +1 more source

Supplemental Material - Increased anti-thrombotic therapy is associated with decreased major adverse limb events in patients with low wound and foot infection scores

, 2023
Supplemental Material for Increased anti-thrombotic therapy is associated with decreased major adverse limb events in patients with low wound and foot infection scores by Chien Y Maximilian Png, Jenna Beardsley, Mitri K Khoury, Sujin Lee, Katherine ...
Chien Yi Maximilian Png (16803931), Sujin Lee (310412), Mitri K. Khoury (16803937), Tiffany R. Bellomo (12032684), Sunita D. Srivastava (16803940), Jenna G. Beardsley (16803934), Anahita Dua (10171083), Katherine L. Morrow (5852942)   +7 more
core   +1 more source

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

Advanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao, Han Wu, Shaorong Li, Weijian Wang, Yijian Guo, Shuai Cheng, Jiayi Sun, Jilong An, Wei Zhang   +8 more
wiley   +1 more source

Major adverse cardiovascular and limb events caused by tirzepatide in patients with type 2 diabetes at high cardiovascular risk: A comparison with sitagliptin.

Diabetes Research and Clinical Practice
AIMS To elucidate the overall protective effects of tirzepatide against atherosclerosis-related events, including cardiovascular and lower-extremity events.
Y. Iwasaki, T. Shimada, T. Kishimori, Takao Kato, Jumpei Koike, Takehiro Matsumoto, T. Yagi, M. Okada   +7 more
semanticscholar   +1 more source

Supplemental Material—Hypogastric artery luminal diameter predicts common-external iliac stent patency and major adverse limb events in patients with aortoiliac occlusive disease

, 2023
Supplementary Material for Hypogastric artery luminal diameter predicts common-external iliac stent patency and major adverse limb events in patients with aortoiliac occlusive disease by Andrew H Smith, Siddhartha Dash, Sean Steenberge, Jon Quatromoni ...
Siddhartha Dash (14650749), Jon G Quatromoni (14650755), Andrew H Smith (3265494), Sean Steenberge (14650752), Linda M Graham (14232848), Levester Kirksey (11511604), Sean P Lyden (14650764), Francis J Caputo (14650761), Jarrad W Rowse (14650758), Christopher J Smolock (14650767)   +9 more
core   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Prognostic Impact of Interleukin-27 in Peripheral Artery Disease

Life
Atherosclerosis is a progressive arterial disease characterized by chronic inflammation, with interleukin-27 (IL-27) implicated as both a pro- and anti-inflammatory cytokine. This prospective cohort study evaluated association of circulating IL-27 levels
Nataša Kokalj, Borut Jug
doaj   +1 more source