Results 181 to 190 of about 1,659,809 (298)

Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review. [PDF]

Neurosci Appl
Serretti A, Fabbri C, Fanelli G, European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Network, Baune BT.   +4 more
europepmc   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Novel and emerging anesthetic drugs for the treatments of major depression: a comprehensive review of efficacy, mechanism, and outlook. [PDF]

Front Psychiatry
Li C, Wang Z, Ye X, Lv J, Chen F, Zhang Y, Liu J, Li X, Duan J, Wang Y, Wang B, Tang W, Zhang J, Teng Y.   +13 more
europepmc   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Posttraumatic stress disorder, major depression, and mild cognitive impairment: A cohort study of world trade center responders. [PDF]

Psychiatry Res
Mann FD, Clouston SAP, Choi J, Hall CB, Zeig-Owens R, Christodoulou C, Fels AM, Fajfer MD, Melendez OA, Hennington CM, Arneaud CW, Zou YF, Fontana AE, Barber A, Mueller AK, Carr MA, Prezant DJ, Luft BJ.   +17 more
europepmc   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Neural correlates of conditional reasoning dysfunction in major depression: An event-related potential study with the Wason selection task. [PDF]

World J Psychiatry
Li JX, Lu MC, Wu LA, Li W, Li Y, Li XP, Liu XH, Gao XZ, Zhou ZH, Zhou HL.   +9 more
europepmc   +1 more source

Therapeutic processes in family groups for hospitalized patients with major depression: a phenomenological study [PDF]

, 2010
Buysse, Ann, De Mol, Jan, Demyttenaere, Koen, Hellemans, Sabine, Lemmens, Gilbert   +4 more
core   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Representation and outcomes of individuals with major depression in routine care who are ineligible for randomized controlled trials: a nationwide register-based study. [PDF]

World Psychiatry
Hamina A, Pinzón-Espinosa J, Taipale H, Schneider-Thoma J, Radua J, Efthimiou O, Cardoner N, Correll CU, Fusar-Poli P, Mittendorfer-Rutz E, Penninx BWJH, Ruhe HG, Tanskanen A, Vinkers CH, Leucht S, Vieta E, Cipriani A, Tiihonen J, Luykx JJ.   +18 more
europepmc   +1 more source