Results 211 to 220 of about 1,659,809 (298)

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression. [PDF]

Imaging Neurosci (Camb)
Taraku B, Nomi JS, Zavaliangos-Petropulu A, Al-Sharif N, Pfeiffer P, Norris V, Joshi S, Espinoza R, Uddin LQ, Narr KL.   +9 more
europepmc   +1 more source

OBUSight: Clinically Aligned Generative AI for Ophthalmic Ultrasound Interpretation and Diagnosis

Advanced Science, EarlyView.
OBUSight, a clinically aligned generative AI model that jointly generates reports and predicts diseases through multimodal semantic alignment, was trained and validated on a large multicenter dataset. OBUSight outperformed eight state‐of‐the‐art models, provided clinically reliable reports, enhanced diagnostic efficiency, and achieved performance ...
Xiaocong Liu, An Shao, Bingtao Guan, Ziyao Luo, Weiyi Lai, Xiaoling Huang, Jun Liu, Jie Yan, Huimin Li, Xiangji Pan, Jiawei Wang, Zichang Su, Yih Chung Tham, Jie Yang, Haotian Lin, Juan Ye, Hongxia Xu, Jian Wu   +17 more
wiley   +1 more source

Intracranial directed connectivity links subregions of the prefrontal cortex to major depression. [PDF]

Nat Commun
Myers J, Xiao J, Mathura RK, Shofty B, Gates V, Adkinson J, Allawala AB, Anand A, Gadot R, Najera R, Rey HG, Mathew SJ, Bijanki K, Banks G, Watrous A, Bartoli E, Heilbronner SR, Provenza N, Goodman WK, Pouratian N, Hayden BY, Sheth SA.   +21 more
europepmc   +1 more source

Mitigating the Rock‐Salt Phase Transformation in Disordered LNMO Through Synergetic Solid‐State AlF3/LiF Modifications

Advanced Science, EarlyView.
The transition between the spinel and rock‐salt phases induces irreversible structural changes in disordered LiNi0.5Mn1.5O4, thereby preventing it from fully releasing its electrochemical capacity during charge/discharge cycling. Abstract High‐voltage disordered spinel LiNi0.5Mn1.5O4 is a promising cathode material for high power density in lithium‐ion
Xingqi Chang, Carlos Escudero, Ashley P Black, Sharona Horta, Elías Martínez, Xuan Lu, Jordi Llorca, Maria Ibáñez, Jordi Jacas Biendicho, Andreu Cabot   +9 more
wiley   +1 more source

Effects of combined exercise training for adults with resistant major depression: a pilot study from the TRACE-RMD project. [PDF]

PeerJ
Tous-Espelosin M, Pavón-Navajas C, Etxaniz-Oses J, Cañas-García MT, Maldonado-Martin S, Orruño-Vivar J, Corres P, Iriarte-Yoller N.   +7 more
europepmc   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

The Presence of the mtDNA4977 Deletion Does Not Necessarily Mean That It is Responsible for Major Depression [Letter]. [PDF]

Neuropsychiatr Dis Treat
Finsterer J.
europepmc   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source