Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. [PDF]
, 2017 BackgroundWe evaluated the orexin receptor antagonist filorexant (MK-6096) for treatment augmentation in patients with major depressive disorder.MethodsWe conducted a 6-week, double-blind, placebo-controlled, parallel-group, Phase II, proof-of-concept ...
Ceesay, Paulette +9 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
The Healing Power of Storytelling: An Exploration into the Autoethnographic Process [PDF]
, 2017 I came to an epiphany as a writer and a person through autoethnography, a research and writing process that analyzes personal experience in the interest of understanding cultural experience.
Cote, Amanda
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Serotonin reuptake inhibitors and cardiovascular disease [PDF]
, 2005 Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Belcher, P.R. +2 more
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Venlafaxine for major depression [PDF]
BMJ, 2007 More evidence that risks outweigh benefits for most patients? In this week's BMJ Rubino and colleagues provide new evidence that informs the debate about whether antidepressants increase the risk of suicide.1 The study, a retrospective observational analysis of the General Practice Research Database, found that patients prescribed venlafaxine were ...
Cipriani, A, Geddes, J, Barbui, C
openaire +2 more sources
CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang +6 more
wiley +1 more source
Childhood trauma: a risk for major depression in patients with psoriasis
Psychiatry and Clinical Psychopharmacology, 2018 INTRODUCTION: A history of childhood trauma is an important determinant for understanding the development of psychiatric and physical disorders. The chronic inflammatory disease, psoriasis, has been reported to be affected by childhood psychological ...
Mercede Erfanian
doaj +1 more source
Evaluating Respiratory Sinus Arrhythmia as a Mediator of Relations between Minority Stress and Depressive Symptoms Among Sexual Minorities [PDF]
, 2020 Compared with heterosexuals, those with sexual minority identities (e.g., lesbian, gay, bisexual) are at significantly greater risk of psychopathology, including depression—the most common mental health disorder in the general population. A large body of
Mustafa, Jazmyn
core
Failure to regulate: counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression [PDF]
, 2007 Although depressed mood is a normal occurrence in response to adversity in all individuals, what distinguishes those who are vulnerable to major depressive disorder (MDD) is their inability to effectively regulate negative mood when it arises ...
Davidson, Richard J. +4 more
core +1 more source
The Effectiveness of the Acceptance and Commitment-based Treatment Matrix Model on Improving the Quality of Life of Patients with Major Depression [PDF]
, 2021 Sara HashemiPoor +2 more
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