Results 101 to 110 of about 193,331 (298)

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source

Association of major depressive disorder with chronic diseases and multimorbidity in Brazilian adults, stratified by gender: 2019 National Health Survey

Revista Brasileira de Epidemiologia
: Objective: To analyze the association of major depressive disorder with chronic non-communicable diseases and multimorbidity in Brazilian adults, stratified by gender, as well as examine the interaction between gender and chronic non-communicable ...
Neuciani Ferreira da Silva Sousa, Marilisa Berti de Azevedo Barros, Lhais de Paula Barbosa Medina, Deborah Carvalho Malta, Celia Landmann Szwarcwald   +4 more
doaj   +2 more sources

A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder [PDF]

, 2002
P. Pancheri, Pierluigi Scapicchio, Roberto Delle Chiaie   +2 more
openalex   +1 more source

Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis

Advanced Science, EarlyView.
Weight cycling in Humans is suspected to dysregulate eating behavior. Mice submitted to body weight cycling by alternating western‐type and regular chow diets display increased hedonic appetite when exposed to a palatable diet, reminiscent of binge‐eating episodes.
Mélanie Fouesnard, Adélie Salin, Sandy Ribes, Magali Monnoye, Gaëlle Champeil‐Potokar, Marie‐Sabelle Hjeij, Gwénaëlle Randuineau, Léa Le Gleau, Selma Ben Fradj, Catherine Philippe, Alexandre Benani, Isabelle Denis, Véronique Douard, Gaëlle Boudry   +13 more
wiley   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Phonologically-based biomarkers for major depressive disorder

EURASIP Journal on Advances in Signal Processing, 2011
Of increasing importance in the civilian and military population is the recognition of major depressive disorder at its earliest stages and intervention before the onset of severe symptoms.
Trevino Andrea, Quatieri Thomas, Malyska Nicolas   +2 more
doaj  

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Enhanced Reaction Kinetics in Sodium‐Ion Batteries Achieved by 3D Heterostructure CoS2/CoS with Self‐Induced Internal Electric Field

Advanced Science, EarlyView.
A novel HC@CoS2/CoS/NC composite with optimized heterointerfaces is successfully synthesized as an ultrastable and fast‐charging anode material for SIBs. This composite features a 3D architecture, characterized by highly dispersed CoS2/CoS/NC nanoparticles embedded within honeycomb carbon nanosheets.
Jin Liang, Jiawen Sun, Xin Cao, Xiaoshan Li, Xiaoyi Chen, Ruizhe Xing, Jie Kong   +6 more
wiley   +1 more source

Autonomous Neurobiological Pathways to Late-Life Major Depressive Disorder Clinical and Pathophysiological Implications [PDF]

, 2002
Anand Kumar, Jim Mintz, Warren Bilker, Gary Gottlieb   +3 more
openalex   +1 more source

Autobiographical memory specificity and the course of major depressive disorder [PDF]

, 2002
Frenk Peeters, Ineke Wessel, Harald Merckelbach, Miranda Boon-Vermeeren   +3 more
openalex   +1 more source