Results 171 to 180 of about 536,691 (337)

MicroRNAs as Regulators of Neuroinflammation in Major Depressive Disorder. [PDF]

Depress Anxiety
Li Q, Ling Y, Gu L, Li L, Liu Y, Ma Y, Ma R, Chen M.   +7 more
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Neuroimmune dysregulation and comorbidity mechanisms of major depressive disorder and migraine. [PDF]

BMC Psychiatry
Liang G, Huang Q, Song W, Pan M, Wei Q, Zeng J, Xie Y, Lan Y, Zou C, Liu X, Huang X, Zou D.   +11 more
europepmc   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Positive memory enhancement training for individuals with major depressive disorder [PDF]

, 2018
De Raedt, Rudi, Hall, K. A. A., Joormann, Jutta, Timpano, Kiara R   +3 more
core   +2 more sources

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis. [PDF]

Aging Cell
Diniz BS, Zhao S, Drouard G, Vuoksimaa E, Ollikainen M, Lenze EJ, Xu M, Fortinsky RH, Kuchel GA, Kaprio J, Kuo CL.   +10 more
europepmc   +1 more source

<p>Efficacy of Eye Movement Desensitization and Reprocessing on the Quality of Life in Patients with Major Depressive Disorder: A Randomized Clinical Trial</p>

, 2020
Abdolhadi Jahanfar, Zhila Fereidouni, Mohammad Behnammoghadam, Azizallah Dehghan, Somayeh Bashti   +4 more
openalex   +2 more sources

Baseline patterns of resting functional connectivity within posterior default-mode intranetwork associated with remission to antidepressants in major depressive disorder

, 2022
Yanxiang Ye, Chengyu Wang, Xiaofeng Lan, Weicheng Li, Ling Fu, Fan Zhang, Haiyan Liu, Kai Wu, Yanling Zhou, Yuping Ning   +9 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source