Results 201 to 210 of about 533,533 (336)

Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities

Advanced Science, EarlyView.
This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao, Lifeng Liang, Ling Yang, Chunyu Lyu, Yang Lyu, Weijun Yang, Jiaran Shi, Wei Wei, Jiahui Cheng, Xiaolei Sun, Xian Zhu, Chao Chen, Xiaoting Xu, Jianchuang Qi, Wenli Li, Yizhe Zhang, Xiao Zhang, Yan Zhou, Aiqiang Dong, Juntao Chen, Bo Li, Kun Yang   +21 more
wiley   +1 more source

Rheumatoid arthitis and major depressive disorder [PDF]

MedUNAB, 2003
Juan Guillermo Lozano de Castro, Boris Miguel Hernández Lizarazo   +1 more
doaj  

Advancing treatment paradigms: the role of psilocybin in managing major depressive disorder. [PDF]

Ann Med Surg (Lond)
Rasheed S, Arif R, Raza AA, Samadi A.
europepmc   +1 more source

A Collection of 120 Psychology Patients with 17 Essential Symptoms to Diagnose Mania Bipolar Disorder, Depressive Bipolar Disorder, Major Depressive Disorder, and Normal Individuals

, 2023
Hengameh Karbalaeipour, Siavash Damari, Mohammad Hossein Zolfagharnasab, Amin Haghdadi   +3 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

What combinations of agomelatine with other antidepressants could be successful during the treatment of major depressive disorder or anxiety disorders in clinical practice? [PDF]

, 2019
Petr Potměšil
openalex   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Utility of therapeutic drug monitoring in the treatment of major depressive disorder. [PDF]

Curr Opin Psychiatry
Schoretsanitis G, Paulzen M.
europepmc   +1 more source

Inflammatory Biomarker and Response to Antidepressant in Major Depressive Disorder: a Systematic Review and Meta-Analysis

Alessandra Gasparini, Camilla Callegari, Giulia Lucca, Alessandro Bellini, Ivano Caselli, Marta Ielmini   +5 more
openalex   +2 more sources

Effectiveness of a placebo effect enhancing intervention as an adjunctive tool in an inpatient-treatment program of major depressive disorder: a parallel-group, randomized controlled study

, 2017
Benedikt B. Claus
openalex   +1 more source