Results 221 to 230 of about 832,143 (393)

Undertreatment of people with major depressive disorder in 21 countries

British Journal of Psychiatry, 2017
G. Thornicroft, S. Chatterji, S. Evans-Lacko, M. Gruber, N. Sampson, S. Aguilar-Gaxiola, A. Al-Hamzawi, J. Alonso, L. Andrade, G. Borges, R. Bruffaerts, B. Bunting, J. C. D. de Almeida, S. Florescu, G. de Girolamo, O. Gureje, J. Haro, Yan-ling He, H. Hinkov, E. Karam, N. Kawakami, Sing Lee, F. Navarro-Mateu, M. Piazza, J. Posada-Villa, Y. T. de Galvis, R. Kessler   +26 more
semanticscholar   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Pharmacogenetics and the Response to Antidepressants in Major Depressive Disorder. [PDF]

Pharmaceuticals (Basel)
Bertollo AG, Mocelin R, Ignácio ZM.
europepmc   +1 more source

Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder

, 2002
E. Serap Monkul, J. P. Hatch, María Aparecida Nicoletti, Susan H. Spence, Paolo Brambilla, Acioly L.T. Lacerda, Roberto B. Sassi, Alan G. Mallinger, Matcheri S. Keshavan, Jair C. Soares   +9 more
openalex   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Selective Serotonin Reuptake Inhibitor and Venlafaxine Use in Children and Adolescents with Major Depressive Disorder: A Systematic Review of Published Randomized Controlled Trials [PDF]

, 2004
Darren Courtney
openalex   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

The Role of Willpower in Major Depressive Disorder: An fMRI Study. [PDF]

Brain Behav
Yulug B, Uygur B, Sayman D, Cankaya S, Ayyıldız B, Ayyıldız S, Oktem EO, Akturk A, Ozsimsek A, Salar AB, Ozansoy M, Hanoglu L, Altay O, Velioglu HA, Mardinoglu A.   +14 more
europepmc   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Adolescent major depressive disorder may predict poor psychosocial functioning in young adulthood [PDF]

, 2004
Neal D. Ryan
openalex   +1 more source