Results 221 to 230 of about 536,691 (337)

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Vortioxetine effectiveness in the treated major depressive disorder patients in Saudi Arabia. [PDF]

Ann Gen Psychiatry
Garatli A, Saad S, Alowesei R, Xavier F, Zeina M, Lofty W, Khalid M, Alharthi N, Talaat T, Asiri SA.   +9 more
europepmc   +1 more source

Social contexts are associated with higher emotional awareness than nonsocial contexts: Evidence in a sample of people with and without major depressive disorder.

Alison B. Tuck, Mallory J. Feldman, Kristen A. Lindquist, Renee J. Thompson   +3 more
openalex   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Overexpression of Hspa1b in the mouse hippocampus may be associated with major depressive disorder. [PDF]

Behav Brain Funct
Zhao X, Shang Y, Zhu W, Wareesawetsuwan N, Zhu L, Li C, Chen J, Bi Y.   +7 more
europepmc   +1 more source

Major Depressive Disorder in the 21^ Century : From Psychobiology to Neuroscience

, 2001
Sidney H. Kennedy
openalex   +1 more source

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source

Uncovering oscillatory dysregulation associated with suicide risk in major depressive disorder: a narrative review. [PDF]

Transl Psychiatry
Dai Z, Jia M, Zhou H, Wang H.
europepmc   +1 more source

Major depressive disorder and immunity to varicella-zoster virus in the elderly

, 2011
Michael R. Irwin, Myron J. Levin, Carmen Carrillo, Richard G. Olmstead, Anne Lucko, Nancy Lang, Michael J. Caulfield, Adriana Weinberg, Ivan S. F. Chan, J. Benjamin St. Clair, Jeff Smith, Rocio D. Marchese, Heather Williams, Danielle Beck, Patricia T. McCook, Gary R. Johnson, Michael N. Oxman   +16 more
openalex   +2 more sources

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source