Results 71 to 80 of about 207,642 (302)

High level of pattern glare in major depressive disorder

BMC Psychiatry, 2019
Background Visual deficits have been reported in abundance by recent studies on major depressive disorder. Pattern glare manifests as visual distortions, such as the symptoms of headache, glare, eyestrain, illusions of shapes, colors, and motion when ...
Xiongwei Qi, Huanhuan Fan, Xiao Yang, Yayun Chen, Wei Deng, Wanjun Guo, Qiang Wang, Eric Chen, Tao Li, Xiaohong Ma   +9 more
doaj   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

A double‐blind comparative trial with mianserin and amitriptyline in outpatients with major depressive disorders. [PDF]

, 1983
JP Feighner, R. Jake Jacobs, RE Jackson, G. GORDON HENDRICKSON, CH Merideth, PD O'Meara   +5 more
openalex   +1 more source

A Feasibility Study of Patients with Major Depression and Substance Use Disorders: Vortioxetine as Maintenance Treatment

Neuropsychiatric Disease and Treatment, 2022
Ignacio Basurte-Villamor,1 Pablo Vega,2 Carlos Roncero,3– 5 José Martínez-Raga,6 Lara Grau-López,7– 10 Lourdes Aguilar,3– 5 Marta Torrens,11 Nestor Szerman12 1Department of Psychiatry and Behavioral Health, Clínica López Ibor, Madrid, Spain; 2Institute ...
Basurte-Villamor I, Vega P, Roncero C, Martínez-Raga J, Grau-López L, Aguilar L, Torrens M, Szerman N   +7 more
doaj  

GENETICS OF MAJOR DEPRESSIVE DISORDER

Bulletin of Problems Biology and Medicine, 2019
Major depressive disorder (MDD) is prevalent psychiatric disease with hereditary liability. It develops as a interaction result of genetic components and certain environmental factors. According to the results of the WHO investigation, the average global prevalence of major depressive disorder is 5%. There is a regional variation of this index, so that
O. I. Berezan, V. M. Pomohaibo, A. V. Petrushov   +2 more
openaire   +2 more sources

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source

Anxiety and autonomic regulation in major depressive disorder: an exploratory study [PDF]

, 1996
J.H.M. Tulen, Jan A. Bruijn, K.J. de Man, Eddy van der Velden, L. Pepplinkhuizen, Arie J. Manin t Veld   +5 more
openalex   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Efficacy of Org 3770 (mirtazapine) vs amitriptyline in patients with major depressive disorder: A meta-analysis [PDF]

, 1995
M. Zivkov, Kit C. B. Roes, Adri G. Pols
openalex   +1 more source

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, EarlyView.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source