Results 71 to 80 of about 832,143 (393)

Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder

Scientific Reports, 2020
Reduced haemodynamic response in the frontotemporal cortices of patients with major depressive disorder (MDD) has been demonstrated using functional near-infrared spectroscopy (fNIRS).
S. F. Husain, Rongjun Yu, T. Tang, W. Tam, B. Tran, Travis T C Quek, Shi-Hui Hwang, Cheryl W. L. Chang, Cyrus S. H. Ho, R. Ho   +9 more
semanticscholar   +1 more source

Gene expression in major depressive disorder [PDF]

Molecular Psychiatry, 2015
The search for genetic variants underlying major depressive disorder (MDD) has not yet provided firm leads to its underlying molecular biology. A complementary approach is to study gene expression in relation to MDD. We measured gene expression in peripheral blood from 1848 subjects from The Netherlands Study of Depression and Anxiety.
Patrick F. Sullivan, Kai Xia, Anke R. Hammerschlag, Danielle Posthuma, Jay A. Tischfield, Y. Milaneschi, Rick Jansen, Fred A. Wright, Fred A. Wright, E.J.C. de Geus, A.T.F. Beekman, Wei Sun, N van der Wee, Vered Madar, Jouke-Jan Hottenga, Robert A. Schoevers, Brenda W.J.H. Penninx, Fei Zou, Dorret I. Boomsma, Jan Smit, Andrew Brooks, G van Grootheest, Gonneke Willemsen   +22 more
openaire   +7 more sources

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source

Understanding the role of P2X7 in affective disorders—are glial cells the major players? [PDF]

, 2015
Pathophysiology associated with several psychiatric disorders has been linked to inflammatory biomarkers. This has generated a theory of major depressive disorders as an inflammatory disease.
Jenkins, Trisha A., Spencer, Sarah J., Stokes, Leanne   +2 more
core   +2 more sources

Hormonal Treatments for Major Depressive Disorder: State of the Art.

American Journal of Psychiatry, 2020
Major depressive disorder is a common psychiatric disorder associated with marked suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030, major depression will be the leading cause of disease burden worldwide ...
J. Dwyer, A. Aftab, A. Widge, C. Rodriguez, L. Carpenter, C. Nemeroff, N. Kalin   +6 more
semanticscholar   +1 more source

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

Annals of Clinical and Translational Neurology, EarlyView.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski, Freddy Chafota, Fangyuan Cao, Amanda Wei Yin Lim, Victor Flores‐Ocampo, Santiago Díaz‐Torres, Zuriel Ceja, Luis M. García‐Marín, Scott F. Farrell, Kishore R. Kumar, Jane Alty, George D. Mellick, Trung Thành Ngô, Miguel E. Rentería   +13 more
wiley   +1 more source

Autobiographical Memories in Major Depressive Disorder [PDF]

Clinical Psychology & Psychotherapy, 2011
The objective of this research was to study the relation between the processing and recall of information in major depressive disorder. An autobiographical memory task was applied to 42 subjects with a diagnosis of major depressive disorder, 28 subjects with a diagnosis of panic disorder and 51 subjects without any psychological disorder.
Claúdio, Victor, Aurélio, João Garcez, Machado, Paulo P. P.   +2 more
openaire   +5 more sources

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort [PDF]

, 2016
BACKGROUND: Late-life sub-threshold depressive symptoms (i.e. depressive symptoms that do not meet the criteria for a diagnosis of major depressive disorder) are associated with impaired physical health and function, and increased risk of major ...
Allan, CL, Ebmeier, KP, Filippini, N, Kivimaki, M, Mackay, CE, Mahmood, A, Sexton, CE, Shipley, MJ, Singh-Manoux, A, Topiwala, A, Zsoldos, E   +10 more
core  

How major depressive disorder affects the ability to decode multimodal dynamic emotional stimuli [PDF]

, 2016
Most studies investigating the processing of emotions in depressed patients reported impairments in the decoding of negative emotions. However, these studies adopted static stimuli (mostly stereotypical facial expressions corresponding to basic emotions)
Esposito, Anna, Likforman-Sulem, Laurence, Scibelli, Filomena, Troncone, Alda, Vinciarelli, Alessandro   +4 more
core   +2 more sources