Results 61 to 70 of about 365,225 (252)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Effect of Heterogeneity in Initial Geographic Distribution on Opinions’ Competitiveness
Entropy, 2015 Spin dynamics on networks allows us to understand how a global consensus emerges out of individual opinions. Here, we are interested in the effect of heterogeneity in the initial geographic distribution of a competing opinion on the competitiveness of ...
Alexander S. Balankin +5 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Impartiality, Anonymity, and Caring Who
Free & EqualIn the last 30 years, a range of powerful arguments have pushed ethics in a utilitarian direction by invoking the principle of Outcome Anonymity, which holds that two outcomes are equally good if they involve the same distribution of welfare, differing ...
Daniel Muñoz
doaj +2 more sources
Mirage of Democracy: The Town Meeting in America
Journal of Deliberative Democracy, 2019 In American mythology, the town meetings of colonial New England are the storied source of the nation’s democracy. But early New Englanders allowed the great majority of their adult males to vote only because they had no other way to secure social order.
Michael Zuckerman
doaj +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
On the intrinsic value of democracy
УправлениеThe article aims to consider the most common arguments in support of democracy as a procedure for making general decisions that is fair in itself, and not in terms of the result achieved.
N. A. Shaveko
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source