Results 91 to 100 of about 1,104 (244)
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openaire +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
MM optimization: Proximal distance algorithms, path following, and trust regions. [PDF]
Landeros A, Xu J, Lange K.
europepmc +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The Schatten p-quasinorm on Euclidean Jordan algebras
In this article, we proved that a Schatten $ p $-(quasi)norm for $ 0 < p < 1 $, defined on Euclidean Jordan algebras, satisfied a relaxed triangle inequality with an optimal constant $ 2^{\frac{1}{p} - 1} $; hence, it indeed induced a quasinorm ...
Juyoung Jeong
doaj +1 more source
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Necessary and sufficient conditions for a bivariate mean of three parameters to be the Schur $m$-power convex [PDF]
Hong-Ping Yin +3 more
doaj +1 more source
Uniform Treatment of Integral Majorization Inequalities with Applications to Hermite-Hadamard-Fejér-Type Inequalities and f-Divergences. [PDF]
Horváth L.
europepmc +1 more source
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source

