Results 81 to 90 of about 1,145 (265)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Multidimensional Scaling Using Majorization: SMACOF in R
Journal of Statistical Software, 2009 In this paper we present the methodology of multidimensional scaling problems (MDS) solved by means of the majorization algorithm. The objective function to be minimized is known as stress and functions which majorize stress are elaborated. This strategy
Jan de Leeuw, Patrick Mair
doaj
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Multidimensional Scaling by Majorization: A Review
Journal of Statistical Software, 2016 A major breakthrough in the visualization of dissimilarities between pairs of objects was the formulation of the least-squares multidimensional scaling (MDS) model as defined by the Stress function.
Patrick J. F. Groenen +1 more
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Nonlinear Sherman-type inequalities
Advances in Nonlinear Analysis, 2018 An important class of Schur-convex functions is generated by convex functions via the well-known Hardy–Littlewood–Pólya–Karamata inequality. Sherman’s inequality is a natural generalization of the HLPK inequality.
Niezgoda Marek
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Generalizations of Several Inequalities Related to Multivariate Geometric Means
Mathematics, 2019 In the paper, by some methods in the theory of majorization, the authors generalize several inequalities related to multivariate geometric means.
Bo-Yan Xi +3 more
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Journal of the Experimental Analysis of Behavior, 2006 For at least three decades, the Psychobiology Laboratory at Harvard Medical School was a major center of discovery in behavior analysis. In the three articles that follow, the principals of this laboratory, Peter Dews, William Morse, and Roger Kelleher, are each the subject of retrospective appreciations focusing on their contributions to behavior ...
openaire +2 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source