Results 141 to 150 of about 5,289 (294)
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Quadratic and Cubic Majorization [PDF]
, 2011 Majorization algorithms generalize the EM algorithm. In this paper we discuss and compare various quadratic and cubic majorization methods, and apply them to logistic ...
Jan de Leeuw
core
Extended Lorenz majorization and frequencies of distances in an undirected network
Journal of Data and Information ScienceTo contribute to the study of networks and graphs.
Egghe Leo
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Some Majorization Techniques [PDF]
, 2006 Majorization algorithms generalize the EM algorithm. In this paper we discuss several distinct, although related, techniques to construct majorization function, and we show the algorithms they ...
de Leeuw, Jan
core
MM optimization: Proximal distance algorithms, path following, and trust regions. [PDF]
Proc Natl Acad Sci U S A, 2023 Landeros A, Xu J, Lange K.
europepmc +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Energy Exploration & ExploitationIn order to reduce energy waste caused by insufficient absorption capacity, improve the stability and reliability of the wind and solar energy storage system, reduce power costs, reduce greenhouse gas emissions, and enhance environmental benefits.
Haonan Dong +4 more
doaj +1 more source