Results 131 to 140 of about 265 (236)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Combining ordered subsets and momentum for accelerated X-ray CT image reconstruction. [PDF]

IEEE Trans Med Imaging, 2015
Kim D, Ramani S, Fessler JA.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A highly accurate family of stable and convergent numerical solvers based on Daftardar-Gejji and Jafari decomposition technique for systems of nonlinear equations. [PDF]

MethodsX
Qureshi S, Argyros IK, Jafari H, Soomro A, Gdawiec K.   +4 more
europepmc   +1 more source

A unified framework for sparse non-negative least squares using multiplicative updates and the non-negative matrix factorization problem. [PDF]

Signal Processing, 2018
Fedorov I, Nalci A, Giri R, Rao BD, Nguyen TQ, Garudadri H.   +5 more
europepmc   +1 more source

Convex optimization algorithms in medical image reconstruction-in the age of AI. [PDF]

Phys Med Biol, 2022
Xu J, Noo F.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tracing human genetic histories and natural selection with precise local ancestry inference. [PDF]

Nat Commun
Lerga-Jaso J, Novković B, Unnikrishnan D, Bamunusinghe V, Hatorangan MR, Manson C, Pedersen H, Osama A, Terpolovsky A, Bohn S, De Marino A, Mahmoud AA, Bircan KO, Khan U, Grabherr MG, Yazdi PG.   +15 more
europepmc   +1 more source

Distance majorization and its applications. [PDF]

Math Program, 2014
Chi EC, Zhou H, Lange K.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source