Results 141 to 150 of about 1,544,255 (266)

BIOINFORMATICS APPLICATIONS NOTE doi:10.1093/bioinformatics/btl007 Sequence analysis

, 2008
Motivation: The first version of the graphical multiple sequence alignment environment QAlign was published in 2003. Heavy response from the molecular-biological user community clearly demonstrated the need for such a platform.
Jens Stoye, Thasso Griebel, Michael Sammeth, Felix Tille, Sequence Analysis   +4 more
core  

Effects of genotype and ecological environment on the community structure and function of symbiotic bacteria in rhizosphere of ginseng. [PDF]

BMC Microbiol, 2022
Zhang J, Liu P, Nie B, Liu X, Zhang Z, He R, Dong W, Ji W.   +7 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Quantifying the Discord: Order Discrepancies in Message Sequence Charts

, 2007
Message Sequence Charts (MSCs) and High-level Message Sequence Charts (HMSC) are formalisms used to describe scenarios of message passing protocols. We propose using Allen's logic to study the temporal order of the messages. We introduce the concept of {\
Genest, Blaise, Elkind, Edith, Peled, Doron, Spoletini, Paola   +3 more
core   +1 more source

Accurate predictions of disordered protein ensembles with STARLING. [PDF]

Nature
Novak B, Lotthammer JM, Emenecker RJ, Holehouse AS.   +3 more
europepmc   +1 more source

Relaxed Linearized Algorithms for Faster X-Ray CT Image Reconstruction. [PDF]

IEEE Trans Med Imaging, 2016
Nien H, Fessler JA.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Generalizations of the quadratic bound optimization principle. [PDF]

Proc Natl Acad Sci U S A
Li XJ, Tian GL, Zhou H, Lange K.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Transcriptional activity of mouse major satellite repeat sequences

Major satellite repeats (MSR) are noncoding repetitive DNA sequences in the mouse genome and a major component of constitutive heterochromatin. Although found within heterochromatin, MSR sequences are transcriptionally competent under stress conditions, during the cell cycle, and early embryonic development.
openaire   +3 more sources