Results 161 to 170 of about 1,544,255 (266)

On local convergence analysis of inexact Newton method for singular systems of equations under majorant condition. [PDF]

ScientificWorldJournal, 2014
Zhou F.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

AI-Powered Mice Behavior Tracking and Its Application for Neuronal Manifold Analysis Based on Hippocampal Ensemble Activity in an Alzheimer's Disease Mice Model. [PDF]

Int J Mol Sci
Gerasimov E, Karasev V, Umnov S, Chukanov V, Pchitskaya E.   +4 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Combining ordered subsets and momentum for accelerated X-ray CT image reconstruction. [PDF]

IEEE Trans Med Imaging, 2015
Kim D, Ramani S, Fessler JA.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Tracing human genetic histories and natural selection with precise local ancestry inference. [PDF]

Nat Commun
Lerga-Jaso J, Novković B, Unnikrishnan D, Bamunusinghe V, Hatorangan MR, Manson C, Pedersen H, Osama A, Terpolovsky A, Bohn S, De Marino A, Mahmoud AA, Bircan KO, Khan U, Grabherr MG, Yazdi PG.   +15 more
europepmc   +1 more source

A unified framework for sparse non-negative least squares using multiplicative updates and the non-negative matrix factorization problem. [PDF]

Signal Processing, 2018
Fedorov I, Nalci A, Giri R, Rao BD, Nguyen TQ, Garudadri H.   +5 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Distance majorization and its applications. [PDF]

Math Program, 2014
Chi EC, Zhou H, Lange K.
europepmc   +1 more source