Results 121 to 130 of about 4,389,343 (333)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
ZygonThe subject of this article is a critique of the philosophy of religion presented by Neil Van Leeuwen in his Religion as Make-Believe: A Theory of Belief, Imagination, and Group Identity.
Konrad Szocik
doaj +2 more sources
For better or for worse? Investigating the meaning of change [PDF]
, 2018 For most, change makes a regular appearance in everyday life and has the capacity to usher in excitement, growth, and chaos. Due to the variable nature of change, people may hold subjective definitions of what “change” typically means.
English, Jaslyn, Wilson, Anne
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
System development issues concerning integration of wind generation in Great Britain [PDF]
, 2009 The European Union has committed itself to sourcing 20% of its energy from renewables by 2020. Britain's excellent wind resource is expected to make a significant contribution to this target, not least from Scotland and the north of England.
Bell, K.R.W.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
NATIONALISM AS AN ESSENTIALLY CONTESTED CONCEPT [PDF]
Journal of Liberty and International Affairs, 2018 Despite the fact that the notion of a state that contains a specific nation is relatively new, most societies tend to perceive their national origins as an indisputable historical fact.
Hamid Bouyahi
doaj
Make/Believe: UK design for performance 2011 – 2015 [PDF]
Curator of selected UK work at the Prague Quadrennial, Prague, Czech Republic, 17 – 28 June ...
Burnett, K
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source