Results 91 to 100 of about 21,379,830 (325)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Battle flags hanging in Ohio History Center plaza
, 1970 Photograph of Ohio's Battle Flag collection hanging in the plaza of the Ohio History Center in Columbus, Ohio, ca. 1970. The flags were displayed on the Center’s plaza level from the time the building opened in 1970 through the late 1980s, when they were
Ohio History Connection
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Making and Knowing (Fake) Coral
, 2014 The video shows the process of making imitation coral in the Making and Knowing Lab, following Ms. Fr. 640, fol. 3r, Coral contrefaict (Counterfeit coral). The Making and Knowing Project with Elisabeth Berry-Drago.
The Making and Knowing Project
core +1 more source
Making history, making place—contextualising the built heritage of world expos 2010 and 2015
Built HeritageBe it the 1873 World’s Fair in Vienna, which established the city's status as a link between the Occident and Orient, or the very first Great Exhibition in 1851 in London, which showcased the then British empire to a global public and the world to its ...
Pascal Honisch
doaj +1 more source
Protecting History, Resisting Legibility: Voice and Defiance in Making Art
Encounters in Theory and History of Education, 2008 A composer/writer reflects on the struggle to create work of integrity in a captive and commodified culture. Approached from a biographical perspective and from the privileged position of a dual Canadian and American citizen, the author explores the ...
Alfred Fisher
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Star Making: A Publishing History of Thea Astley
eTropic: electronic journal of studies in the tropics, 2016 This article focuses directly on Thea Astley’s publishing history from the time of her involvement with Brisbane’s avant garde in the 1950s, her early inclusion in regional collections, and her emergence as a Miles Franklin prize-winning author, through ...
Deborah Jordan, Louise Poland
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source