Results 41 to 50 of about 256,768 (294)

‘Eradication was a dirty word’: Anti-gambiae campaign, between cooperation and rivalry (1938–1940)

Global Public Health, 2023
This article analyzes the efforts of the International Health Division of the Rockefeller Foundation (IHDRF) in its project initiative that resulted in the extermination of the African mosquito Anopheles gambiae from Brazil in 1940.
Gabriel Lopes, Marcos Cueto
doaj   +1 more source

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source

Transgenic tomato plants expressing the antigen gene PfCP-2.9 of Plasmodium falciparum

Pesquisa Agropecuária Brasileira, 2013
The objective of this work was to obtain transgenic tomato plants expressing the PfCP-2.9 protein (a chimera of the antigens MSP1 and AMA1 of Plasmodium falciparum).
Mihail Kantor, Radu Sestras, Kamal Chowdhury   +2 more
doaj   +1 more source

Estudo da resistência aos anti-maláricos: desenvolvimento de um novo teste de sensibilidade do Plasmodium spp., baseado na detecção de hemozoína [PDF]

, 2009
Tese de mestrado, Bioquímica (Bioquímica Médica), Universidade de Lisboa, Faculdade de Ciências, 2009A malária é conhecida pela sua elevada morbilidade e mortalidade.
Meira, Teresa Maria Monteiro Maurício Lopes
core  

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Água, saúde e territórios : uma breve discussão [PDF]

, 2013
A água e o meio ambiente, recursos vitais, interagem de várias maneiras com a saúde humana: vetor de agente microbiano ou tóxicos, ambiente de vida de vetores biológicos ou ainda importante meio de favorecimento de desenvolvimento de epidemias durante e ...
Billa, Michèle, Gurgel, Helen da Costa, Mazzega, Pierre   +2 more
core   +3 more sources

AIEgen‐Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control

Advanced Science, EarlyView.
An intelligent early warning and treatment system for monkeypox, utilizing a sprayable AIEgen‐ liquid dressing (AIE@LD) that responds to lesion pH. Integrated with a smartphone app and cloud platform, it enables real‐time infection detection via fluorescence imaging and triggers on‐demand photodynamic therapy under white light, effectively eradicating ...
Wei Wang, Zining Liu, Mengjun Li, Judun Zheng, Ruilin Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jingze Yu, Meijia Pan, Fengbo Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao   +14 more
wiley   +1 more source

Avaliação da incidência da deficiência de Glicose-6-Fosfato Desidrogenase (G6PD) e perfil hematológico em indivíduos de uma região de Rondônia Incidence evaluation of Glucose-6-Phosphate Dehydrogenase and hematological profile in Rondonia

Revista Brasileira de Hematologia e Hemoterapia, 2004
O estudo compreendeu a avaliação da deficiência de Glicose-6-Fosfato Desidrogenase (G6PD) e perfil hematológico em 122 indivíduos (69 homens e 53 mulheres), com idade variando entre 3 a 84 anos, selecionados conforme a aceitação em participação no estudo,
Tony H. Katsuragawa, Luiz H. Soares Gil, Rodrigo G. Stábile, Matheus G. Pires, Cláudia R. Bonini-Domingos   +4 more
doaj   +1 more source

Malaria: a retrospective study of clinical suspected infection cases by Plasmodium sp. between 2010 and 2014 [PDF]

, 2016
[PT] A malária é uma infeção parasitária causada por um protozoário intracelular obrigatório (género Plasmodium), cuja transmissão é assegurada quando uma fémea de mosquito género Anopheles infetada efetua a sua refeição de sangue num indivíduo. Estão
Ferreira, Idalina, Gargate, Maria João, Martins, Susana, Reis, Tânia, Vilares, Anabela   +4 more
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