Results 71 to 80 of about 188,346 (245)
Chemistry – A European Journal, EarlyView.We report the first chemical synthesis of a 183‐residue functional truncated cyclic PfAMA1 domain I protein using multi‐segment native chemical ligation and head‐to‐tail cyclization to introduce conformational constraints, thereby facilitating protein folding and providing novel strategies for miniature protein engineering.
Jamsad Mannuthodikayil +4 more
wiley +1 more source
Estudo clínico da malária falciparum em crianças em Manaus, AM, Brasil [PDF]
, 2000 Elza Ferreira Noronha +3 more
openalex +3 more sources
O ciclo exoeritrocitário dos parasitos da malária [PDF]
, 1944 W. Lobato Paraense
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Chemistry – A European Journal, EarlyView.The synthesis of betulinic acid and echinocystic acid saponins featuring QS‐21 minimal immunogenic motif is reported. These chimeric saponins, together with previously synthesized Lewis‐X‐containing triterpenoid saponins and a rhamnose‐modified saponin, were assessed for their toxicological and immunological profiles in wild‐type and/or hDC‐SIGN ...
Oscar Javier Gamboa Marin +9 more
wiley +1 more source
A Novel Inhibitor against the Bromodomain Protein 1 of the Malaria Pathogen Plasmodium Falciparum
ChemMedChem, EarlyView.This article presents the development of a first‐in‐class inhibitor targeting the bromodomain protein PfBDP1 in Plasmodium falciparum, the deadliest variant of the malaria‐causing Plasmodium parasites. Through structure‐based drug design, the inhibitor interactions were characterized via X‐ray crystallography and isothermal titration calorimetry ...
Marius Amann +10 more
wiley +1 more source
Dinâmica estacional de uma população de Anopheles darlingi, numa área endêmica de malária no Amazonas [PDF]
, 1979 Jack Hayes, J. D. Charlwood
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Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites
ChemMedChem, EarlyView.Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert +6 more
wiley +1 more source
Estudo sobre malária e parasitoses intestinais em indígenas da tribo Nadëb-Maku, Estado do Amazonas, Brasil [PDF]
, 1984 Odair Genaro, José João Ferraroni
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Dose Determinations at Drug Approval Reviews: FDA‐Approved Drugs in Past 5 Years
Clinical Pharmacology &Therapeutics, EarlyView.Drug dose appropriateness is one of the most discussed issues in regulatory reviews. We analyzed dose determinations during Food and Drug Administration (FDA) drug reviews to determine whether there were changes between the proposed and approved doses of new molecular entities (NMEs), including cases where postmarketing dose‐finding studies were ...
Sachiko Mita, Shunsuke Ono
wiley +1 more source
ASPECTOS DA ENFERMAGEM NA PROFILAXIA E TRATAMENTO DA DOENÇA DE CHAGAS, DA MALÁRIA E DA ESQUITOSSOMOSE [PDF]
, 1980 Izaura Lopes de Godoy
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