Results 41 to 50 of about 527,308 (312)

Sobre la identidad del “físico” citado en la col. IV del papiro de Derveni

Emerita, 2014
Se intenta establecer qué filósofo o, en su defecto, movimiento filosófico, satisface la doctrina sobre la plegaria y el azar que el comentarista del papiro de Derveni atribuye al «físico» que cita en la col.
Carlos Megino
doaj   +1 more source

Oppositely Charged Single Enzyme Nanogels Form Versatile Coacervates for Efficient Enzyme Cascade Catalysis

Advanced Materials, EarlyView.
Oppositely charged single enzyme nanogels (SENs) phase‐separate into bi‐enzymatic coacervate microdroplets, acting as both scaffold and functional units. By tuning SEN ratios, these coacervates create specific microenvironments that enable selective small‐molecule enrichment and efficient intermediate diffusion.
Andoni Rodriguez‐Abetxuko, Nadia A. Erkamp, Neshat Moslehi, Yannick H. A. Leurs, Lars Paffen, Işil Yeşil Gür, Jana Stojanović, Hugo Brasselet, Laura van der Weel, Ulf Hanefeld, Ilja K. Voets, Jan C. M. van Hest   +11 more
wiley   +1 more source

Nanotherapeutic interventions to enhance cisplatin sensitivity in ovarian cancer cells

Egyptian Journal of Medical Human Genetics
Globally, ovarian cancer is the third most common female malignancies causing mortality. Cisplatin is the first line of therapy for treating ovarian cancer (OC), its therapeutic efficacy is severely limited owing to emergence of drug resistance ...
Disha Mittal, Anita Kamra Verma
doaj   +1 more source

Akitlerden Sonra Fiyatta veya Malın Miktarında Değişiklik: İslam Hukuku Perspektifinden Bir Analiz

İslam Hukuku Araştırmaları Dergisi
Bu çalışmada, bağlayıcı bir akit kurulduktan sonra, tarafların rızaları doğrultusunda fiyatta veya malın miktarındaki değişikliğin mahiyeti ve sonuçları incelenmektedir.
Ramazan Araz
doaj   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

El sufrimiento y el perdón. Aportes levinasianos

Humanidades, 2017
Este artículo tiene como objeto situar y problematizar lo que es para mí uno de los temas más importantes de nuestro tiempo: el sufrimiento, entendido como mal, y el perdón, como recurrencia al Bien.
Analía Giménez Giubbani
doaj   +1 more source

Vaccine uptake and associated factors in an irregular urban settlement in northeastern Brazil: a cross-sectional study

BMC Public Health, 2020
Background Globally, childhood immunization saves the lives of 2–3 million children annually by protecting them against vaccine-preventable diseases. In 2017, 116.2 million children were vaccinated worldwide according to the World Health Organization ...
Ana Amélia Corrêa de Araújo Veras, Eduardo Jorge da Fonseca Lima, Maria de Fátima Costa Caminha, Suzana Lins da Silva, Amanda Alves Moreira de Castro, Andressa Lílian Bezerra Bernardo, Maria Lídia Amaral Barbosa Ventura, Pedro Israel Cabral de Lira, Malaquias Batista Filho   +8 more
doaj   +1 more source

Mal - mau [Orto e grafia]

, 2016
Conhecimentos curriculares das séries iniciais do Ensino FundamentalEpisódio do programa Orto e Grafia que ensina o uso escrito e falado das palavras mau, má, mal e derivadas destasComponente Curricular::Ensino Fundamental::Séries Iniciais::Língua ...
Brasil. Ministério da Educação (MEC)
core   +1 more source

Tissue targeting was found with Pt-Mal-LHRH.

, 2023
Tissues were harvested from untreated 12 wk old female Balb/c mice and LHRH receptor protein was analyzed via western blotting. Increased LHRH receptor expression was found in reproductive tissues compared to normal bladder tissue control, with a ...
Lindsay Cormier (17124820), Jason Unrine (1661014), Margaret Ndinguri (829018), Aggie Williams (17124817), Emma Nienaber (17124811), Cassidy Spease (17124814), Lisa Middleton (17124805), Shu Lui (17124808), Joseph Rollins (829017)   +8 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source