Results 51 to 60 of about 3,692,753 (275)

All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery

Advanced Science, EarlyView.
Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi, Brooke E. Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y. Ma, Chinmay S. Potnis, Soumen Saha, Xinghai Li, Max R. Ney, Sarah Y. Kim, Joshua J. Milligan, Lixin Fan, Matthew L. Becker, Daniel Reker, Ashutosh Chilkoti   +15 more
wiley   +1 more source

Akitlerden Sonra Fiyatta veya Malın Miktarında Değişiklik: İslam Hukuku Perspektifinden Bir Analiz

İslam Hukuku Araştırmaları Dergisi
Bu çalışmada, bağlayıcı bir akit kurulduktan sonra, tarafların rızaları doğrultusunda fiyatta veya malın miktarındaki değişikliğin mahiyeti ve sonuçları incelenmektedir.
Ramazan Araz
doaj   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Noninvasive tests for nonalcoholic fatty liver disease in a multi‐ethnic population: The HELIUS study

Hepatology Communications, EarlyView., 2022
Abstract Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence and severity globally, prompting noninvasive testing, yet limited data exist on noninvasive liver tests (NITs) including transient elastography (TE) in ethnically diverse populations.
Anne‐Marieke van Dijk, Yasaman Vali, Anne Linde Mak, Henrike Galenkamp, Max Nieuwdorp, Bert‐Jan van den Born, Adriaan Georgius Holleboom   +6 more
wiley   +1 more source

El sufrimiento y el perdón. Aportes levinasianos

Humanidades, 2017
Este artículo tiene como objeto situar y problematizar lo que es para mí uno de los temas más importantes de nuestro tiempo: el sufrimiento, entendido como mal, y el perdón, como recurrencia al Bien.
Analía Giménez Giubbani
doaj   +1 more source

Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine

Advanced Science, EarlyView.
An engineered MOF nanomedicine (MAL) triggers cascade nanocatalysis in tumors, converting H2O2 and L‐Arg into cytotoxic peroxynitrite. This induces DNA damage, activates the p53 pathway, and amplifies mitochondrial apoptosis via the BAX/Bcl‐2/Caspase‐3 axis, effectively inhibiting colorectal cancer growth with high biocompatibility.
Tan Wu, Xiaoyue Xu, Dan Xu, Hui Zhang, Nan Wang, Yang Yang, Qian Chen, Shunjie Chen, Cheng Li   +8 more
wiley   +1 more source

¿Son convincentes los argumentos de Epicuro y Lucrecio para rechazar el temor a la muerte?

Areté, 2022
Este artículo se ocupa de reconstruir y evaluar los principales argumentos epicúreos contra la idea de que la muerte es un mal para quien muere. Para combatir la vida angustiada por el temor a la muerte, Epicuro y Lucrecio despliegan una serie de ...
Sergi Rosell
doaj  

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

Mal absoluto, mal radical, banalidad del mal. La comprensión del mal en Hannah Arendt

Bajo Palabra, 2019
The aim of this article is to provide a panoramic exposition of Hannah Arendt’s thought about the issue of evil. In order to achieve this task, I will pose briefly Kant’s approach of ‘radical evil’, which had an enormous relevance for Arendt. Then, I will point out the stance held by her in The Origins of Totalitarianism and later to explain the way ...
openaire   +3 more sources

Mal-Adjusted: Integration of Selves in Joss Whedon\u27s \u3ci\u3eFirefly\u3c/i\u3e [PDF]

, 2009
Joss Whedon’s Firefly and Serenity offer a brand new take on the well established science fiction film genre, one that many authors and viewers believe needed Whedon’s fresh new ideas to prevent further stagnating of the genre.
Buscemi, Rose
core   +1 more source