Results 41 to 50 of about 58,711,078 (135)

Evaluating the Performance of Traditional Pharmacoepidemiologic and Machine Learning Models to Predict Pregnancies at Risk of Major Congenital Malformations

Birth Defects Research, Volume 118, Issue 9, September 2026.
ABSTRACT Background With approximately 50% of pregnancies being unplanned, there is an unintended exposure to potential feto‐toxic drugs that may cause major congenital malformations (MCM). This study aims to compare the predictive performance between traditional pharmacoepidemiologic (PE) and machine learning (ML) models. Methods We conducted a cohort
Gabra Nohmie, Marc Lanovaz, Odile Sheehy, Cristina Longo, Robert Platt, Audrey Durand, Christine Damase‐Michel, Anick Bérard   +7 more
wiley   +1 more source

Paroxysmal Kinesigenic Dyskinesia and Progressive Ataxia‐Spasticity Syndrome Caused by a Biallelic Variant in KCNJ10

Movement Disorders Clinical Practice, EarlyView.
Clément Desjardins, Jiyoon Baik, Lorenzo Bresciani, Christelle Nilles, Cendrine Foucard, Mathieu Georget, Lina Daghsen, Bertrand Degos, Aurélie Méneret, Emmanuel Roze   +9 more
wiley   +1 more source

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 721-730, September 2026.
Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan, Odile Sheehy, Lisiane Freitas Leal, Vanina Tchuente, Anick Bérard   +4 more
wiley   +1 more source

Drug Repurposing for Parkinson's Disease Prevention: Replication Study of Three Drugs in French Healthcare Databases

Movement Disorders, EarlyView.
Yanis Saidi, Anne Paakinaho, Eeva Pylkkö, Sirpa Hartikainen, Anna‐Maija Tolppanen, Alexis Elbaz, Ismaïl Ahmed, Anne C.M. Thiébaut, Émeline Courtois   +8 more
wiley   +1 more source

ALY688 Protects Against Myocardial Ischemia‐Reperfusion Injury via Direct Effects and Rab8a‐Dependent Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
This study identifies ALY688, a synthetic adiponectin receptor agonist, as a potent cardioprotective agent against ischemia‐reperfusion injury. ALY688 reduced infarct size, cardiomyocyte death, and oxidative stress, while preserving cardiac function. Mechanistically, it enhanced extracellular vesicle (EV) number through Rab8a‐dependent signaling and ...
Hye Kyoung Sung, Jialing Tang, Yubin Lei, Khang Nguyen, Eddie Tam, Jun Wu, Ren‐Ke Li, Vincent Richard, Christoph H. Borchers, Lina Antounians, Dylan Burger, Augusto Zani, Gary Sweeney   +12 more
wiley   +1 more source

Antisélection en Assurance Automobile et Impact des Jours de Carence sur les Arrêts Maladies

, 2017
Cet après midi, je suis à Paris-Jourdan pour la soutenance de thèse d'Alexandre Godzinski , sur Three empirical essays on moral hazard identification in insurance, supervisée par Pierre-Yves Geoffard.
Arthur Charpentier
core   +1 more source

Association of treated neovascular AMD with disability and mood disorders: A longitudinal nationwide study

Acta Ophthalmologica, Volume 104, Issue 6, Page e648-e654, September 2026.
Abstract Purpose To describe the associations of treated neovascular AMD with the risk of disability, falls, fractures and mood disorders in a large sample representative of the French population. Methods Analyses were based on 77 582 individuals belonging to the ‘Echantillon Généraliste des Bénéficiaires’, a 1/97 random sample of the French population,
Cécile Delcourt, Emilie Hucteau, Sarra Gattoussi, Karine Pérès, Marie‐Noelle Delyfer, Catherine Helmer, Jean‐François Korobelnik   +6 more
wiley   +1 more source

Optimizing Perioperative Management of Haemophilia B With rFIX‐FP: Pharmacokinetic Validation of the Hemoptidose Tool

Haemophilia, Volume 32, Issue 5, Page 1179-1187, September/October 2026.
ABSTRACT Background Surgical management of haemophilia B requires precise factor IX replacement to ensure adequate haemostasis while optimizing factor consumption. Extended half‐life rFIX‐FP simplifies perioperative management but exhibits substantial pharmacokinetic variability.
Xavier Delavenne, Célia Vollard, Nicolas Drillaud, Sabine Castet, Nicolas Luyck, Emilie Hénin, Julien Denis‐Le Seve, Fabienne Volot, Brigitte Tardy, Stéphanie Désage, Benoît Guillet   +10 more
wiley   +1 more source

Les Mémoires de la forêt : Quand l’âpreté de la maladie côtoie la douceur gourmande de l’amitié

, 2023
Dans Les Mémoires de la forêt : quand l’âpreté de la maladie côtoie la douceur gourmande de l’amitié, Elsa Nguyen, assistante doctorante à la HEPL donne la parole à Alice, jeune lectrice de 5H, et recueille celle de l’auteur Mickaël Brun-Arnaud ...
Nguyen, Elsa
core  

Bioethics and Medical Litigation in France: An Exploratory Study

Journal of Evaluation in Clinical Practice, Volume 32, Issue 6, September 2026.
ABSTRACT Aims and Objectives Medical litigation is a matter of particular concern for hospitals. We decided to examine whether bioethics might offer additional insights into these disputes. Method We conducted a highly exploratory and descriptive study in empirical bioethics, relying exclusively on a sample of scientific articles addressing medical ...
Rania Nader, Henri‐Corto Stoeklé, Louisa Smail Shehba, Pascal Jazat, Christian Hervé   +4 more
wiley   +1 more source