Results 111 to 120 of about 137,891 (245)

Immunoinformatics-Based Multi-Epitope Vaccine Design Against <i>P. falciparum-</i>Causing Malaria: A Computational Approach. [PDF]

Health Sci Rep
ABSTRACT Background and Aim Malaria is an infectious disease that affects people in Africa, and other parts of the world by the millions. Despite the effectiveness of artemisinin‐based combination therapies against the disease, current findings on possible Plasmodium resistance to artemisinin warrants an exploration of new treatment options. This study
Larbi AA, Mensah C, Korankye R, Darkwah AA, Agyemang EB, Ayikpah IY, Kwarteng A.   +6 more
europepmc   +2 more sources

Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum. [PDF]

, 2015
BackgroundPlasmodium falciparum, the deadliest malaria-causing parasite, has an extremely AT-rich (80.7 %) genome. Because of high AT-content, sequence-based annotation of genes and functional elements remains challenging.
Bunnik, Evelien M, Le Roch, Karine G, Lonardi, Stefano, Lu, Xueqing Maggie, Nasseri, Sara, Pokhriyal, Neeti   +5 more
core   +2 more sources

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Cross sectional study to determine chloroquine resistance among Plasmodium falciparum clinical isolates from Khartoum, Sudan [version 1; referees: 1 approved, 2 approved with reservations]

F1000Research, 2018
Background:  Malaria continues to present a global health threat; the World Health Organization (WHO) reported 214 million cases of malaria by the year 2015 with a death rate of 438000.
Walaa Salah Abdulla Mohammed, Kyakonye Yasin, N.S. Mahgoub, Muzamil Mahdi Abdel Hamid   +3 more
doaj   +1 more source

Changes in metabolic phenotypes of Plasmodium falciparum in vitro cultures during gametocyte development. [PDF]

, 2014
BACKGROUND: Gametocytes are the Plasmodium life stage that is solely responsible for malaria transmission. Despite their important role in perpetuating malaria, gametocyte differentiation and development is poorly understood.
Delves, MJ, Lamour, SD, Saric, J, Straschil, U   +3 more
core   +3 more sources

Highly divergent apicomplexan cytoskeletons provide additional models for actin biology

The FEBS Journal, EarlyView.
Actin is a highly conserved, abundant and central molecule in eukaryotes. Apicomplexans contain some of the most sequence‐divergent actin cytoskeletons known. This divergence results in overlapping yet different biochemical properties. Here, we highlight the remarkable divergence of the actin cytoskeleton by comparing apicomplexan to classical systems,
Yukino Kobayashi, Ross G. Douglas
wiley   +1 more source

FBN30 in wild Anopheles gambiae functions as a pathogen recognition molecule against clinically circulating Plasmodium falciparum in malaria endemic areas in Kenya

Scientific Reports, 2017
Malaria is a worldwide health problem that affects two-thirds of the world population. Plasmodium invasion of anopheline mosquitoes is an obligatory step for malaria transmission.
Guodong Niu, Genwei Zhang, Caio Franca, Yingjun Cui, Stephen Munga, Yaw Afrane, Jun Li   +6 more
doaj   +1 more source

Detection of Plasmodium falciparum male and female gametocytes and determination of parasite sex ratio in human endemic populations by novel, cheap and robust RTqPCR assays [PDF]

, 2017
The presence of Plasmodium falciparum gametocytes in peripheral blood is essential for human to mosquito parasite transmission. The detection of submicroscopic infections with gametocytes and the estimation of the gametocyte sex ratio are crucial to ...
Alano, Pietro, Avellino, Pamela, Lombardo, Fabrizio, Mangano, Valentina Dianora, Modiano, David, Ouédraogo, Jean Bosco, Santolamazza, Federica, Siciliano, Giulia, Yao, Franck Adama   +8 more
core   +2 more sources

New Evidence of TLR4 and TLR9 Variants Influencing Parasitaemia and Symptoms of Plasmodium vivax Infection

International Journal of Immunogenetics, EarlyView.
ABSTRACT Toll‐like receptors (TLRs) induce the production of pro‐inflammatory cytokines and regulate the immune response to Plasmodium vivax infection. Genetic variants of TLRs are associated with susceptibility and severity of malaria in different populations. This study aimed to evaluate the association between polymorphisms in TLR1, TLR4, TLR7, TLR8,
Mikaele Monik Rodrigues Inácio Silva, Gabriela Maria Andrade Correia, Juliana Dal‐Ri Lindenau, Maristela Gomes Cunha, Maria Deise Oliveira Ohnishi, Ana Maria Revoredo Silva Ventura, Ândrea Ribeiro‐dos‐Santos, Mara Helena Hutz, Vinicius Albuquerque Sortica   +8 more
wiley   +1 more source

A reiterative method for calculating the early bactericidal activity of antituberculosis drugs.

, 2002
Studies of early bactericidal activity (EBA) are important in the rapid evaluation of new antituberculosis drugs. Historically, these have concentrated on the log fall in the viable count in sputum during the first 48 hours of therapy.
Charalambous, Bambos M, Gillespie, Stephen H, Gosling, Roland D   +2 more
core   +1 more source