Results 121 to 130 of about 242,726 (257)

Cross sectional study to determine chloroquine resistance among Plasmodium falciparum clinical isolates from Khartoum, Sudan [version 1; referees: 1 approved, 2 approved with reservations]

F1000Research, 2018
Background:  Malaria continues to present a global health threat; the World Health Organization (WHO) reported 214 million cases of malaria by the year 2015 with a death rate of 438000.
Walaa Salah Abdulla Mohammed, Kyakonye Yasin, N.S. Mahgoub, Muzamil Mahdi Abdel Hamid   +3 more
doaj   +1 more source

Spotlight on the Nucleotide: Solid‐State NMR for the Investigation of ATP Hydrolysis in the ATPase SmsC

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Nucleotide‐detected solid‐state NMR has been applied to probe nucleotide conformations and dynamics during ATP hydrolysis using the dimeric P‐loop ATPase SmsC as a model protein. The different stages of ATP hydrolysis have been mimicked by ATP analogues for which different degrees of conformational heterogeneity have been observed. ABSTRACT Solid‐state
Nina Wehr, Laure Decamps, Julius Schlüter, Koen Linssen, Georg Künze, Kushal Sengupta, Serena DeBeer, Thomas Wiegand   +7 more
wiley   +1 more source

Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study [PDF]

, 2006
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a major pathogenicity factor in falciparum malaria that mediates cytoadherence. PfEMP1 is encoded by approximately 60 var genes per haploid genome.
Cortés, Alfred, Rowe, J Alexandra; id_orcid, Beck, Hans-Peter, Baea, Kay, Kaestli, Mirjam, Cockburn, Ian A   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, Volume 600, Issue 17, Page 2547-2563, September 2026.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Development of a Multi‐Organ Microphysiological (MPS) Model to Study Age‐Related Comorbidities

Advanced Biology, Volume 10, Issue 9, September 2026.
This study developed a human‐based organ‐on‐a‐chip model for the comorbidity of sarcopenia and hypertrophic cardiomyopathy (HCM). The microphysiological system (MPS) co‐cultured skeletal muscle of sarcopenia pathology, cardiomyocytes of HCM pathology, and healthy hepatocytes in a circulated serum‐free common medium.
Gaurav Srivastava, Aakash Patel, Alice Rodriguez‐Fuguet, Akanksh Jambagi, Himanshi Jangir, Ahmad Nawaz, Afeef Mahmud, Camden Dwelle, Xiufang Guo, James Hickman   +9 more
wiley   +1 more source

Association of CD40L gene polymorphism with severe Plasmodium falciparum malaria in Indian population

Journal of Vector Borne Diseases, 2017
Background & objectives: Many host genetic factors are associated with the disease severity and fatal outcome of falciparum malaria. CD40L gene has been found to be one of the most important factors associated with malaria in African countries.
Prasanta Purohit, Pradeep Kumar Mohanty, Siris Patel, Padmalaya Das, Kishalaya Das, Jogeswar Panigrahi   +5 more
doaj  

Design, Synthesis, and Evaluation of New 1,4‐Naphthoquinone‐1,2,3‐triazoles as Antimalarial Agents

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Compound 9g, a 1,4‐naphthoquinone‐1,2,3‐triazole derivative, exhibited potent activity against P. falciparum 3D7 and in silico analysis revealed strong interactions with 1J3 and 1LDG targets, while MD simulations confirmed the stability of the ligand‐3FGO complex.
Lina Rezainia, Mohammad Hosein Sayahi, Eisa Kaveh Vernousfaderani, Seyedeh Sara Mirfazli, Mohammad Hossein Morshedsolouk, Navid Dastyafteh, Mehdi Nateghpour, Leila Farivar, Mina Saeedi, Haleh Hanifian, Mahdi Mohebali, Seyedeh Mana Shafiee, Gholamreza Hassanpour, Mohammad Mahdavi   +13 more
wiley   +1 more source

MALARIA IN PEDIATRIC AGE GROUP: A STUDY OF 200 CASES

Pakistan Armed Forces Medical Journal, 2018
and resistance to various drugs in children. Design: Descriptive observational Place and duration of study: From 1st April 2002 to 31st March 2004 at Department of Pediatrics, CMH Attock. Material and methods: Children upto 12 years of age with
Muhammad Musarrat Jamal, Jehan Ara, Nadir Ali   +2 more
doaj   +2 more sources

Prevalence of non-falciparum malaria infections among asymptomatic individuals in four regions of Mainland Tanzania

Parasites & Vectors
Background Recent studies point to the need to incorporate the detection of non-falciparum species into malaria surveillance activities in sub-Saharan Africa, where 95% of the world’s malaria cases occur.
Zachary R. Popkin-Hall, Misago D. Seth, Rashid A. Madebe, Rule Budodo, Catherine Bakari, Filbert Francis, Dativa Pereus, David J. Giesbrecht, Celine I. Mandara, Daniel Mbwambo, Sijenunu Aaron, Abdallah Lusasi, Samwel Lazaro, Jeffrey A. Bailey, Jonathan J. Juliano, Julie R. Gutman, Deus S. Ishengoma   +16 more
doaj   +1 more source

Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Malaria remains a major health crisis in tropical regions, with Sub‐Saharan Africa bearing the heaviest burden. While insecticide‐treated nets and artemisinin‐based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug
Ashenafi Woldemichael Woime
wiley   +1 more source