Results 141 to 150 of about 137,891 (245)

Impact of NLRP1 Met1154Val and IL1B variants on gestational malaria: an unexplored role of NLRP1 in inflammasome activation by Plasmodium spp.

The Journal of Pathology, Volume 267, Issue 3, Page 304-314, November 2025.
Abstract We hypothesized that variants in inflammasome‐related genes could influence susceptibility to gestational malaria (GM). To test this, we conducted an association study in a cohort of pregnant women from a malaria‐endemic region in northern Brazil, assessing whether specific functional single nucleotide variants (SNVs) in inflammasome genes ...
Vinicius NC Leal, Jessica A Ribeiro, Leticia Girardi Marra, Alexandre TT Rio, Edione C Reis, Gerhard Wunderlich, Jamille G Dombrowski, Claudio RF Marinho, Alessandra Pontillo   +8 more
wiley   +1 more source

Plasmodium vivax malaria presenting with severe thrombocytopenia

Brazilian Journal of Infectious Diseases
Plasmodium falciparum and Plasmodium vivax malaria are endemic infections in India and are commonly associated with mild hematological abnormalities. Severe thrombocytopenia is common in isolated falciparum and mixed falciparum/vivax malaria, but is very
Ravinder Pal Singh Makkar, Surabhi Mukhopadhyay Amitabh Monga, Ajay Kr. Gupta   +2 more
doaj   +1 more source

Ligand binding Pro‐miscuity of acylpeptide hydrolase, structural analysis of a detoxifying serine hydrolase

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Acylpeptide hydrolase (APEH) or acylaminoacyl‐peptidase (AAP) is a serine hydrolase that regulates protein metabolism. It can also bind to and process unusual substrates, acting as a detoxifier. To better understand its promiscuous specificity, we determined the cryo‐EM structures of mammalian APEH complexed with classical serine protease ...
Anna J. Kiss‐Szemán, Luca Takács, Imre Jákli, Zoltán Bánóczi, Naoki Hosogi, Daouda A. K. Traore, Veronika Harmat, András Perczel, Dóra K. Menyhárd   +8 more
wiley   +1 more source

Enrichment of Helminth Mitochondrial Genomes From Faecal Samples Using Hybridisation Capture

Molecular Ecology Resources, Volume 25, Issue 8, November 2025.
ABSTRACT New approaches are urgently needed to enrich rare or low‐abundant DNA in complex samples. Soil‐transmitted helminths (STHs) inhabit heterogeneous environments, including the gastrointestinal tract of their host as adults and are excreted as eggs and larvae in faeces, complicating our understanding of their biology and the use of genetic tools ...
Marina Papaiakovou, Andrea Waeschenbach, Roy M. Anderson, Piet Cools, Zeleke Mekonnen, D. Timothy J. Littlewood, Cinzia Cantacessi, Stephen R. Doyle   +7 more
wiley   +1 more source

Variations in haematological and inflammatory biomarkers and their association with Plasmodium falciparum malaria: a cross-sectional comparative study at a clinic in Ghana

Malaria Journal
Background Malaria remains a significant public health challenge in Ghana, with haematological alterations being a common feature of infection. Understanding these changes is crucial for improving disease management, particularly in endemic regions where
Jaiyeola Kofi Bohli, Patrick Boateng Ansah, Turkson Ephraim Kwamena, Emmanuel Allotey, Richard Vikpebah Duneeh, Ernest Boateng Yeboah, Lynda Addo, Ransford Kyeremeh, Precious Kwablah Kwadzokpui, Kenneth Ablordey   +9 more
doaj   +1 more source

Neutrophils at the Maternal‐Fetal Interface: Agents of Protection or Destruction?

American Journal of Reproductive Immunology, Volume 94, Issue 5, November 2025.
ABSTRACT Neutrophils, traditionally recognized for their role in innate immunity, have emerged as a key cell population at the maternal‐fetal interface, during both uncomplicated and pathological pregnancies. Neutrophil effector functions, including phagocytosis, neutrophil extracellular trap formation, and degranulation, can play protective roles ...
Sallie L. Fell, Sydney M. Nemphos, James E. Prusak, Amitinder Kaur, Jamie O. Lo, Jennifer A. Manuzak   +5 more
wiley   +1 more source

Internationally Adopted and Migrant Children Had Important Health Issues Requiring Systematic Initial Screening at Arrival

Acta Paediatrica, Volume 114, Issue 11, Page 2830-2837, November 2025.
ABSTRACT Aim Internationally adopted and migrant children have similar profiles as they may have experienced many adversities before arrival in their new country. We sought to compare both groups at arrival, focusing on nutritional status, infections and vaccination status.
Céline Lafay, Laurie Miller, Juliette Goutines, Enora Leroux, Albert Faye, Frédéric Sorge   +5 more
wiley   +1 more source

Batch Synthesis of Primaquine Diphosphate Anti‐Malarial Drug

Chemistry – A European Journal, Volume 31, Issue 59, October 22, 2025.
According to the WHO, a child under the age of five dies every 2 minutes from malaria in Africa. It is therefore paramount that access and availability of anti‐malarial drugs must be improved. We report a process for the synthesis of Primaquine Diphosphate, where key intermediates were obtained in a much shorter reaction time compared to processes ...
Faith M. Akwi, Simthandile Swartbooi, Paul Watts   +2 more
wiley   +1 more source

Comparison of the Clinical Profile and Complications of Mixed Malarial Infections of Plasmodium Falciparum and Plasmodium Vivax versus Plasmodium Falciparum Mono-infection

Sultan Qaboos University Medical Journal, 2011
Objectives: This study aimed to compare the clinical presentations and complications in patients having mixed malaria infection of Plasmodium falciparum and Plasmodium vivax with those of patients with malaria due to a P.
Vivek Joseph, Muralidhar Varma, Sudha Vidhyasagar, Alvin Mathew   +3 more
doaj  

Not all that is malaria is falciparum

The Lancet Infectious Diseases, 2008
Brian Angus, Andrew Brent, Andrew Brent
openaire   +5 more sources