Results 31 to 40 of about 326,986 (255)

Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity. [PDF]

open access: yes, 2009
BACKGROUND: The understanding of the epidemiology of severe malaria in African children remains incomplete across the spectrum of Plasmodium falciparum transmission intensities through which communities might expect to transition, as intervention ...
Abdullah Al-Taiar   +25 more
core   +1 more source

The pathophysiology of falciparum malaria

open access: yesPharmacology & Therapeutics, 2003
Falciparum malaria is a complex disease with no simple explanation, affecting organs where the parasite is rare as well as those organs where it is more common. We continue to argue that it can best be understood in terms of excessive stimulation of normally useful pathways mediated by inflammatory cytokines, the prototype being tumor necrosis factor ...
Clark, Ian A, Cowden, William
openaire   +3 more sources

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

open access: yesNew England Journal of Medicine, 2014
BACKGROUND Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria.
E. Ashley   +82 more
semanticscholar   +1 more source

Plasmodium falciparum population dynamics during the early phase of anti-malarial drug treatment in Tanzanian children with acute uncomplicated malaria. [PDF]

open access: yes, 2011
BACKGROUND\ud \ud This study aimed to explore Plasmodium falciparum population dynamics during the early phase of anti-malarial drug treatment with artemisinin-based combination therapy in children with clinical malaria in a high transmission area in ...
Carlsson, A.M   +51 more
core   +1 more source

Cytokine profiles among patients co-infected with Plasmodium falciparum malaria and soil borne helminths attending Kampala International University Teaching Hospital, in Uganda

open access: yesAllergy, Asthma & Clinical Immunology, 2018
Background Malaria and helminths share the same geographical distribution in tropical Africa. Studies of the interaction of helminth and malaria co-infection in humans have been few and are mainly epidemiological, with little information on cellular ...
Richard Bwanika   +3 more
doaj   +1 more source

Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

open access: yesLancet. Infectious Diseases (Print), 2019
Summary Background The emergence and spread of resistance in Plasmodium falciparum malaria to artemisinin combination therapies in the Greater Mekong subregion poses a major threat to malaria control and elimination.
Rob W. van der Pluijm   +44 more
semanticscholar   +1 more source

A world malaria map: Plasmodium falciparum endemicity in 2007 [PDF]

open access: yes, 2009
BACKGROUND: Efficient allocation of resources to intervene against malaria requires a detailed understanding of the contemporary spatial distribution of malaria risk. It is exactly 40 y since the last global map of malaria endemicity was published.
Guerra, C.A.   +66 more
core   +1 more source

Haematological parameters, haemozoin-containing leukocytes in Sudanese children with severe Plasmodium falciparum malaria

open access: yesJournal of Infection in Developing Countries, 2018
Introduction: Haemozoin –containing leucocytes (HCL) can be used to predict severe malaria. Methodology: A case –control study was conducted in Singa, Sudan, to investigate the haematological values and HCL in children with severe Plasmodium ...
Magdi M Salih   +6 more
doaj   +1 more source

IgM in human immunity to Plasmodium falciparum malaria

open access: yesScience Advances, 2019
IgM is an important and long-lived component of anti-malarial immunity in humans and blocks infection of red blood cells. Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain ...
M. Boyle   +40 more
semanticscholar   +1 more source

A comparison of thick-film microscopy, rapid diagnostic test, and polymerase chain reaction for accurate diagnosis of Plasmodium falciparum malaria

open access: yesMalaria Journal, 2019
Accurate diagnosis of malaria is important for effective disease management and control. In Cameroon, presumptive clinical diagnosis, thick-film microscopy (TFM), and rapid diagnostic tests (RDT) are commonly used to diagnose cases of Plasmodium ...
Kenji O. Mfuh   +8 more
semanticscholar   +1 more source

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