Results 41 to 50 of about 62,668 (198)

Variable effects of non-falciparum species infections on malaria disease severity in high transmission regions in Senegal

Tropical Medicine and Health
In malaria endemic countries, non-falciparum species are often mixed with Plasmodium falciparum in patients with uncomplicated malaria, and their contribution to malaria severity and death is poorly studied.
Aissatou Diagne, Babacar Souleymane Sambe, Folly Mawulolo Gaba, Ibrahima Sarr, Arona Sabène Diatta, Ousmane Sadio, Serigne Ousmane Mbacké Diaw, Hélène Ataume Mawounge Diatta, Babacar Diouf, Inès Vigan-Womas, Babacar Mbengue, Makhtar Niang   +11 more
doaj   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Rapid antigen detection tests for malaria diagnosis in severely ill Papua New Guinean children: a comparative study using Bayesian latent class models. [PDF]

PLoS ONE, 2012
BACKGROUND: Although rapid diagnostic tests (RDTs) have practical advantages over light microscopy (LM) and good sensitivity in severe falciparum malaria in Africa, their utility where severe non-falciparum malaria occurs is unknown.
Laurens Manning, Moses Laman, Anna Rosanas-Urgell, Berwin Turlach, Susan Aipit, Cathy Bona, Jonathan Warrell, Peter Siba, Ivo Mueller, Timothy M E Davis   +9 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Membandingkan Status Hematologis Pasien Malaria Falciparum dengan Vivax di RSUP M. Djamil Januari 2011 – Maret 2013

Jurnal Kesehatan Andalas, 2014
AbstrakMalaria merupakan masalah kesehatan yang besar di daerah tropis dan subtropis termasuk di Indonesia. Jenis malaria yang sering terjadi di daerah Sumatera adalah malaria falciparum dan vivax.
Miftahul Jannah Afdhal, Nurhayati ., Julizar .   +2 more
doaj  

Antibody responses to P. falciparum blood stage antigens and incidence of clinical malaria in children living in endemic area in Burkina Faso

BMC Research Notes, 2017
Background High parasite-specific antibody levels are generally associated with low susceptibility to Plasmodium falciparum malaria. This has been supported by several studies in which clinical malaria cases of P.
Mariama K. Cherif, Oumarou Ouédraogo, Guillaume S. Sanou, Amidou Diarra, Alphonse Ouédraogo, Alfred Tiono, David R. Cavanagh, Theisen Michael, Amadou T. Konaté, Nora L. Watson, Megan Sanza, Tina J. T. Dube, Sodiomon B. Sirima, Issa Nebié   +13 more
doaj   +1 more source

Genomic Content in Avian Haemosporidian Parasites Suggests Co‐Regulation of Apicoplast and Mitochondrial Nucleoids

Integrative Zoology, EarlyView.
Apicoplast genomic content and mitochondrial genomic content were found to be strongly correlated (rho = 0.93) for infections going from low to high. Apicoplast and mitochondrial genomic content were deemed as more predictive factors of parasitemia for different infection intensities.
Gaia Porporato, Peter Pibaque, Alanis Cruz Flores, Simone Cescutti, Nayden Chakarov   +4 more
wiley   +1 more source

Parasitaemia and Its Relation to Hematological Parameters and Liver Function among Patients Malaria in Abs, Hajjah, Northwest Yemen

Interdisciplinary Perspectives on Infectious Diseases, 2016
Plasmodium falciparum malaria is the most common infection in Yemen. The present study aims to investigate changes in hematological and hepatic function indices of P. falciparum infected individuals.
Mohamed Al-Salahy, Bushra Shnawa, Gamal Abed, Ahmed Mandour, Ali Al-Ezzi   +4 more
doaj   +1 more source

Genetic Manipulation of Non-Falciparum Human Malaria Parasites

Frontiers in Cellular and Infection Microbiology, 2021
The development of genetic manipulation of Plasmodium falciparum in the 1980s was key to study malaria biology. Genetically modified parasites have been used to study several aspects of the disease, such as red blood cell invasion, drug resistance ...
Taís Baruel Vieira, Thafne Plastina Astro, Roberto Rudge de Moraes Barros   +2 more
doaj   +1 more source