Results 41 to 50 of about 242,726 (257)

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria [PDF]

, 2008
Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have
Walter-Sack, Ingeborg, Coulibaly, Boubacar, Sié, Ali, Schirmer, R. Heiner, Zoungrana, Augustin, Meissner, Peter E., Müller, Olaf, Kouyaté, Bocar, Klose, Christina, Mockenhaupt, Frank P., Mansmann, Ulrich   +10 more
core   +1 more source

Non-falciparum malaria infections in Uganda, does it matter? A review of the published literature

Malaria Journal
Background Plasmodium falciparum is the dominant malaria species in the sub-Saharan Africa and the main cause of severe disease and death. Notwithstanding, severe malaria and death due to non-falciparum infections have been reported, but at much lower ...
Mansour Ranjbar, Yonas Tegegn Woldemariam   +1 more
doaj   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

Application of commercial ultrafiltration membranes for protein purification by high performance countercurrent membrane purification (HPCMP)

Biotechnology Progress, EarlyView.
Abstract High performance countercurrent membrane purification (HPCMP) has emerged as a promising diffusive separation strategy for the purification of recombinant proteins and monoclonal antibodies (mAbs). However, prior studies employed dialysis membranes, which are designed for diffusive separations but have not been validated for biopharmaceutical ...
Aylin Mohammadzadehmarandi, Nate Heller, Mohammadreza Ahmadimashhadi, Jon Petrone, Nicholas Marchand, Siavash Darvishmanesh, Ka Zhang, Stefano Menegatti, Andrew L. Zydney   +8 more
wiley   +1 more source

Nephropathy in falciparum malaria

Kidney International, 1988
Observation chez un homme de 33 ans. Traitement par quinine en intraveineuse et guerison 32 jours plus tard avec un taux serique de creatinine a 1,1 mg ...
openaire   +2 more sources

HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults. [PDF]

PLoS ONE, 2015
HIV infected individuals in malaria endemic areas experience more frequent and severe malaria episodes compared to non HIV infected. This clinical observation has been linked to a deficiency in antibody responses to Plasmodium falciparum antigens ...
Krishanthi S Subramaniam, Jeff Skinner, Emil Ivan, Eugene Mutimura, Ryung S Kim, Catherine M Feintuch, Silvia Portugal, Kathryn Anastos, Peter D Crompton, Johanna P Daily   +9 more
doaj   +1 more source

The treatment of falciparum malaria

Parasitology Today, 1988
Effective treatment for falciparum malaria has been available for over 300 years, and for most of this time physicians have argued over the best doses and the methods of administering antimalarial drugs. A reasonable consensus has since emerged on the treatment of uncomplicated malaria, but there is still disagreement over the management of severe ...
openaire   +2 more sources

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Invasive Bacterial Co-infection in African Children with Plasmodium falciparum Malaria: A Systematic Review. [PDF]

, 2014
Severe malaria remains a major cause of pediatric hospital admission across Africa. Invasive bacterial infection (IBI) is a recognized complication of Plasmodium falciparum malaria, resulting in a substantially worse outcome.
Maitland, Kathryn, Church, James, Church, K, James Church, Kathryn Maitland   +4 more
core   +2 more sources

Variable effects of non-falciparum species infections on malaria disease severity in high transmission regions in Senegal

Tropical Medicine and Health
In malaria endemic countries, non-falciparum species are often mixed with Plasmodium falciparum in patients with uncomplicated malaria, and their contribution to malaria severity and death is poorly studied.
Aissatou Diagne, Babacar Souleymane Sambe, Folly Mawulolo Gaba, Ibrahima Sarr, Arona Sabène Diatta, Ousmane Sadio, Serigne Ousmane Mbacké Diaw, Hélène Ataume Mawounge Diatta, Babacar Diouf, Inès Vigan-Womas, Babacar Mbengue, Makhtar Niang   +11 more
doaj   +1 more source