Results 71 to 80 of about 242,726 (257)

M1 macrophage features in severe Plasmodium falciparum malaria patients with pulmonary oedema

Malaria Journal, 2020
Background Pulmonary oedema (PE) is a serious complication of Plasmodium falciparum malaria which can lead to acute lung injury in severe cases. Lung macrophages are activated during malaria infection due to a complex host-immune response.
Aekkarin Klinkhamhom, Supattra Glaharn, Charit Srisook, Sumate Ampawong, Srivicha Krudsood, Stephen A. Ward, Parnpen Viriyavejakul   +6 more
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Insecticide-treated bednets for the prevention of Plasmodium falciparum malaria in Cambodia: a cluster-randomized trial.

, 2006
OBJECTIVES: To validate and quantify the impact of insecticide-treated bednets (ITN) on malaria morbidity and mortality in Cambodia. METHODS: A paired, cluster-randomized trial of ITN was conducted in Rattanakiri, North East Cambodia.
Hewitt, S, Socheat, D, Rowland, M, Nguon, C, Okell, L, Sochantha, T, Vannara, H, Alexander, N, Yeung, S   +8 more
core   +1 more source

Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malaria. [PDF]

, 2007
A recently proposed mechanism of protection for haemoglobin C (HbC; beta6Glu-->Lys) links an abnormal display of PfEMP1, an antigen involved in malaria pathogenesis, on the surface of HbC infected erythrocytes together with the observation of reduced ...
Warimwe, George M, Bull, PC, Osier, Faith HA, Warimwe, GM, Verra, Federica, David Modiano, Blot Isa, Blot, Isa, Tetteh, KK, Federica Verra, Williams, TN, Howard, Tevis, Warimwe, George, TETTEH KK, BULL PC, Avellino, P, Simpore Jacques, Fegan Greg, Conway David J., Bancone, Germana, Osier, FHA, Marsh Kevin, Warimwe George M., Conway, DJ, Fegan, G, Bull Peter C., MARSH K, Jacques Simpore, Avellino, Pamela, Verra Federica, SIMPORE J, Howard, T, David J. Conway, Modiano David, Conway, David J, Faith H A Osier, WILLIAMS TN, Thomas N. Williams, FEGAN G, Simpore, Jacques, Kevin Marsh, Bancone Germana, Avellino Pamela, Bull, Peter, Bancone, G, David J Conway, Tetteh Kevin K., Peter C. Bull, Germana Bancone, Thomas N Williams, Verra, F, Kevin K. Tetteh, Simpore, J, Greg Fegan, Faith H. A. Osier, VERRA F, Modiano, D, Kevin K Tetteh, Pamela Avellino, Blot, I, Osier Faith H. A., Osier, FH, Howard Tevis, George M Warimwe, George M. Warimwe, WARIMWE GM, HOWARD T, CONWAY DJ, Marsh, K, Modiano, David, BLOT I, Peter C Bull, Williams, Thomas N, Fegan, Greg, Isa Blot, OSIER FH, Tetteh, Kevin K, Williams, Thomas, Marsh, Kevin, Tevis Howard, Bull, Peter C, Williams Thomas N.   +81 more
core   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Influence of the number and timing of malaria episodes during pregnancy on prematurity and small-for-gestational-age in an area of low transmission

BMC Medicine, 2017
Background Most evidence on the association between malaria in pregnancy and adverse pregnancy outcomes focuses on falciparum malaria detected at birth.
Kerryn A. Moore, Julie A. Simpson, Jacher Wiladphaingern, Aung Myat Min, Mupawjay Pimanpanarak, Moo Kho Paw, Jathee Raksuansak, Sasithon Pukrittayakamee, Freya J. I. Fowkes, Nicholas J. White, François Nosten, Rose McGready   +11 more
doaj   +1 more source

Effects of Video‐Based Health Education on Birth Outcomes and Anaemia Status of Mothers in Dirashe District South Ethiopia: A Cluster Randomized Controlled Trial

Maternal &Child Nutrition, EarlyView.
ABSTRACT Undernutrition and infections during pregnancy result in low birth weight (LBW) and maternal anaemia. Social behaviour change communication (SBCC) can promote recommended health practices, potentially improving maternal and neonatal outcomes.
Wanzahun Godana Boynito, Kidus Temesgen Worsa, Befikadu Tariku Gutema, Yordanos Gizachew Yeshitila, Godana Yaya Tessema, Tsegaye Yohanis, Stefaan De Henauw, Piet Cools, Bruno Levecke, Souheila Abbeddou   +9 more
wiley   +1 more source

Comparative assessment of clinic-laboratory profile of different species of severe malaria in a tertiary care institute in southern India

Journal of Vector Borne Diseases, 2019
Background & objectives: Majority of the studies on severe malaria in India have concentrated on falciparum and have been done in northern part.
Thomas Kuncheria, Nithyananda K Chowta, Deepak Madi, Mukta N Chowta, A Basavaprabhu   +4 more
doaj  

A Genetically Encoded Marker for Imaging of Internal Plasmodium Membranes

Molecular Microbiology, EarlyView.
IMMP is a peptide‐based marker that labels internal membranes across multiple stages and species of the malaria‐causing parasite Plasmodium. It works in both live and fixed samples and supports long‐term live‐cell imaging. ABSTRACT Fluorescence microscopy is a powerful tool to analyze the subcellular architecture, and long‐term live‐cell imaging ...
Leah Zink, Viola Reuschenbach, Samy Sid Ahmed, Muriel Lauer, Jana Niethammer, Aistė Kudulytė, Katharina Zorko, Oliver T. Fackler, Franziska Hentzschel, Markus Ganter   +9 more
wiley   +1 more source

Case-control approach to identify Plasmodium falciparum polymorphisms associated with severe malaria. [PDF]

, 2009
BACKGROUND: Studies to identify phenotypically-associated polymorphisms in the Plasmodium falciparum 23 Mb genome will require a dense array of marker loci.
David J Conway, Conway, David J, Chokejindachai, Watcharee, Watcharee Chokejindachai   +3 more
core   +1 more source