Results 81 to 90 of about 242,726 (257)

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, EarlyView.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.

, 2006
In Rwanda, amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) is the current first-line treatment for malaria, introduced in 2001 as an interim strategy before the future deployment of an artemisinin-based combination treatment (ACT).
van Overmeir, C, Karema, Corine, Ngamije, D., D'Alessandro, U., Ngamije, D, Fanello, C. I., van Doren, W., van Doren, W, Karema, C., Fanello, Caterina I, Fanello, Caterina I., D'Alessandro, Umberto, Van Overmeir, C., Fanello, CI, d' Alessandro, Umberto, van Geertruyden, Jean-Pierre, Ngamije, Daniel, van Overmeir, Chantal, van Doren, Walli, D'Alessandro, U, Karema, C, van Geertruyden, JP, Van Geertruyden, J. P.   +22 more
core   +1 more source

Ethics, economics, and the use of primaquine to reduce falciparum malaria transmission in asymptomatic populations. [PDF]

, 2014
Yoel Lubell and colleagues consider ethical and economic perspectives on mass drug administration of primaquine to limit transmission of P. falciparum malaria.
Richard J Maude, Maude, RJ, Arjen Dondorp, Michael Parker, Shunmay Yeung, Drake, Tom, Lisa White, White, Lisa, White, Nicholas J, Parker, M, Yeung, Shunmay, Day, NP, Nicholas P J Day, Drake, T, Yeung, S, Yoel Lubell, Day, Nicholas PJ, Varadan, S, White, L, Dondorp, A, Lubell, Y, Varadan, Sheila, Parker, Michael, Cheah, PY, Sheila Varadan, Nicholas J White, Dondorp, Arjen, Tom Drake, Day, Nicholas, White, NJ, Cheah, Phaik Yeong, White, Nicholas, Maude, Richard J, Lubell, Yoel, Phaik Yeong Cheah   +34 more
core   +1 more source

Plasmodium Actin‐Like Proteins 3 and 5a Are Required for Subsequent Steps of Mosquito Infection

Molecular Microbiology, EarlyView.
Actin‐like proteins (Alps) are highly conserved, apicomplexan‐specific members of the actin superfamily. Using reverse genetics, we have identified that Alp3 and Alp5a are required at separate steps of transmission of the malaria parasite to its mosquito host.
Caroline Busse, Yukino Kobayashi, Andrea Diers, Annika M. Binder, Friedrich Frischknecht, Ross G. Douglas   +5 more
wiley   +1 more source

Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria [PDF]

, 2012
BACKGROUND: Severe malaria has been attributed to the expression of a restricted subset of the var multi-gene family, which encodes for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).
Rottman, Matthias, Beck, Hans-Peter, Beck, H. P., Rottmann, M., Beck Hans-Peter, Mugasa, Joseph, Rusch, Sebastian, Rottmann, Matthias, Mugasa, J., Qi, W., Qi Weihong, Qi, Weihong, Rusch, S., Rusch Sebastian, Rottmann Matthias, Mugasa Joseph   +15 more
core   +1 more source

Indoor residual spraying of distinct insecticide formulations in a household‐scale micro‐mosaic format: Feasibility and effectiveness for malaria vector control in rural Zambia

Medical and Veterinary Entomology, EarlyView.
Densities of all Anopheles species were approximately comparable across all IRS regimes. No differences observed between treatment regimes regarding species composition of the Anopheles funestus group or An. gambiae complex. This operational pilot demonstrates the practical feasibility of IRS micro‐mosaics, despite the inherent increase in deployment ...
Dingani Chinula, Kenzo Mumba, Reuben Zulu, Ketty Ndhlovu, Deogratius R. Kavishe, Neil Philip Hobbs, Samson Kiware, Thomas Reed, Busiku Hamainza, Gerry F. Killeen   +9 more
wiley   +1 more source

PfHPRT: a new biomarker candidate of acute Plasmodium falciparum infection.

, 2013
Plasmodium falciparum is a protozoan parasite that causes human malaria. This parasitic infection accounts for approximately 655,000 deaths each year worldwide. Most deaths could be prevented by diagnosing and treating malaria promptly.
Conway, David J, Ramaprasad, A, Nwakanma, Davis C, Njie, Madi, Fischer, Roman, Digleria, Katalin, Walther, M, Walther, Michael, Conway, DJ, Kessler, BM, Fischer, R, Nwakanma, DC, Thézénas, Marie L, Digleria, K, Kessler, Benedikt M, Ramaprasad, Abhinay, Huang, H, Casals-Pascual, C, Thézénas, ML, Huang, Honglei, Casals-Pascual, Climent, Njie, M   +21 more
core   +1 more source

Open-label comparative clinical study of chlorproguanil−dapsone fixed dose combination (Lapdap™) alone or with three different doses of artesunate for uncomplicated plasmodium falciparum malaria [PDF]

, 2008
The objective of this study was to determine the appropriate dose of artesunate for use in a fixed dose combination therapy with chlorproguanil−dapsone (CPG−DDS) for the treatment of uncomplicated falciparum ...
Peter A Winstanley, Nyirenda, Maggie, Kanjala, Maxwell K., Molyneux, Malcolm, Sam Dunyo, Stephan Duparc, Paula L Kirby, Winstanley Peter A., Kirby, Paula L., Blencowe, Hannah, Daniel G Wootton, Woessner, Mary, Thomas Kanyok, Stephen Ward, Opara, Hyginus, Molyneux Malcolm, Winstanley, Peter A, Wootton Daniel G., Maggie Nyirenda, Ward, Stephen, Dunyo, Sam, Giancarlo A Biagini, Kanjala, Maxwell K, Nyirenda Maggie, Kanyok Thomas, Maxwell K Kanjala, Opara Hyginus, Duparc, Stephan, Kanyok, Thomas, Queen Dube-Mbeye, Duparc Stephan, Malcolm Molyneux, Neate, Colin, Biagini, Giancarlo A, Biagini Giancarlo A., Ward Stephen, Kirby Paula L., Wootton, Daniel G., Wootton, Daniel G, Kirby, Paula L, Hannah Blencowe, Mary Woessner, Kanjala Maxwell K., Molyneux, Malcolm E., Biagini, Giancarlo A., Woessner Mary, Dube-Mbeye Queen, Colin Neate, Hyginus Opara, Neate Colin, Blencowe Hannah, Dunyo Sam, Winstanley, Peter, Dube-Mbeye, Queen, Ward, Steve, Biagini, Giancarlo; id_orcid, Winstanley, Peter A.   +56 more
core   +1 more source

Falciparum Malaria

, 2001
Malaria is one of the most common infectious diseases in the world today, being the most important parasitic infection, and Plasmodium falciparum is the organism responsible for most of the mortality [1]. It has been estimated that approximately 300–500 million people contract malaria every year, with approximately 1–2 million deaths, most of these ...
Feldman, C., Richards, G. A.
openaire   +1 more source

Uncomplicated Malaria in Infancy and Neurodevelopment at 1 and 6 Years: Evidence From the MiPPAD Birth Cohort Study of Benin

Tropical Medicine &International Health, EarlyView.
ABSTRACT In malaria‐endemic regions, repeated episodes of uncomplicated malaria during infancy are common; however, their associations with neurodevelopment remain unclear. We examined relationships between malaria frequency in infancy and neurodevelopmental outcomes in early and middle childhood, using data from the APEC birth cohort nested within the
Juthathip Khongpetch, Michael J. Boivin, Michel Cot, Jacqueline Milet, Roméo Zoumenou, Christophe Fermanian, Achille Massougbodji, Florence Bodeau‐Livinec   +7 more
wiley   +1 more source