Results 91 to 100 of about 697,481 (397)

“We witnessed medicines help our children, then we became proud”: experiences and acceptability of seasonal malaria chemoprevention in Aweil, South Sudan

Malaria Journal
Background Malaria remains a significant public health concern, particularly in resource-constrained settings and regions affected by ongoing humanitarian crises, such as Northen Bahr el Ghazal in South Sudan.
Francis Okot, Maria Suau Sans, Erica Viganò, Abubaker Rom, Denis Mubiru, Kevin Baker, Jamshed Khan, Ahmed Julla   +7 more
doaj   +1 more source

COVID-19 knowledge, beliefs, prevention behaviours and misinformation in the context of an adapted seasonal malaria chemoprevention campaign in six northern Nigerian States

Tropical Medicine and Health, 2020
Background Seasonal malaria chemoprevention (SMC) using sulfadoxine-pyrimethamine and amodiaquine is an efficacious intervention for protection of children against Plasmodium falciparum malaria during the rainy season.
Sol Richardson, Taiwo Ibinaiye, Jamilu Nikau, Olusola Oresanya, Madeleine Marasciulo, Arantxa Roca-Feltrer, Christian Rassi, Olatunde Adesoro   +7 more
doaj   +1 more source

Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin

Cytoskeleton, EarlyView.
ABSTRACT The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore‐associated factor.
Franziska Hentzschel, Friedrich Frischknecht, Matthias Marti   +2 more
wiley   +1 more source

Using the role model approach to optimise caregiver administration of sulfadoxine-pyrimethamine amodiaquine to children aged 3–59 months in Burkina Faso, Chad and Togo: findings from an evaluation

Malaria Journal
Background Seasonal malaria chemoprevention (SMC) is a World Health Organization-recommended intervention for the prevention of malaria among children at high risk in areas with seasonal transmission.
Laura Donovan, Muhammad Shafique, Alexandra Wharton-Smith, Sol Richardson, Erica Viganò, Adama Traore, Cheick Compaoré, Narcisse Tounaikok, Beakgoube Honoré, Nodjiyam Dingamtel, Fantche Awokou, Essèboè Sewu, Gauthier Tougri, Mahamat Saleh Issakha Diar, Tinah Atcha-Oubou, Charlotte Ward, Kevin Baker   +16 more
doaj   +1 more source

Insecticide resistance patterns in Uganda and the effect of indoor residual spraying with bendiocarb on kdr L1014S frequencies in Anopheles gambiae s.s.

Malaria Journal, 2017
Background Resistance of malaria vectors to pyrethroid insecticides has been attributed to selection pressure from long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), and the use of chemicals in agriculture.
Tarekegn A. Abeku, Michelle E. H. Helinski, Matthew J. Kirby, James Ssekitooleko, Chris Bass, Irene Kyomuhangi, Michael Okia, Godfrey Magumba, Sylvia R. Meek   +8 more
doaj   +1 more source

Shifting transmission risk for malaria in Africa with climate change: a framework for planning and intervention

Malaria Journal, 2019
Malaria continues to be a disease of massive burden in Africa, and the public health resources targeted at surveillance, prevention, control, and intervention comprise large outlays of expense.
S. Ryan, C. Lippi, F. Zermoglio
semanticscholar   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Costs of single-phase door-to-door insecticide-treated net mass distribution campaigns in Nigeria: a case study in Ondo and Anambra states

Malaria Journal
Background The distribution of insecticide-treated nets (ITNs) through mass campaigns remains a cornerstone of malaria vector control. As new ITN products are introduced to address rising insecticide resistance, understanding the cost of such campaigns ...
Godstime Eigbiremolen, Bolade Jimoh, Divine Ndubuisi Obodoechi, Abiola O. Oluwagbemiga, Azuka Iwegbu, Saliu Ogunmola, Nonso Ndibe, Waheed A. Folayan, Olusola Oresanya, Kolawole Maxwell, Tarekegn A. Abeku   +10 more
doaj   +1 more source

Maternal environment shapes the life history and susceptibility to malaria of Anopheles gambiae mosquitoes. [PDF]

, 2011
BACKGROUND: It is becoming generally recognized that an individual's phenotype can be shaped not only by its own genotype and environmental experience, but also by its mother's environment and condition.
Koella, Jacob C, Koella Jacob C, Lorenz, Lena M, Lorenz Lena M, Jacob C Koella, Lena M Lorenz   +5 more
core   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source