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Malaria Vaccines: From the Past towards the mRNA Vaccine Era [PDF]
Vaccines, 2023 Plasmodium spp. is the etiological agent of malaria, a life-threatening parasitic disease transmitted by infected mosquitoes. Malaria remains a major global health challenge, particularly in endemic regions.
Chrysa Voyiatzaki, Antonia Efstathiou
exaly +4 more sources
Human Vaccines & Immunotherapeutics, 2021 Malaria vaccines hold significant promise for life-saving benefit, especially to children who bear the major burden of malaria mortality. The RTS,S/AS01 malaria vaccine provides moderate efficacy and is being tested in implementation studies. In parallel,
Matthew B. Laurens
doaj +5 more sources
A Research Agenda for Malaria Eradication: Vaccines [PDF]
PLoS Medicine, 2011 Vaccines could be a crucial component of efforts to eradicate malaria. Current attempts to develop malaria vaccines are primarily focused on Plasmodium falciparum and are directed towards reducing morbidity and mortality.
malERA Consultative Group on Vaccines
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British Medical Bulletin, 2002 Malaria kills one child in Africa every 30 s. After summarising the burden of malaria, the life-cycle of this parasite in humans and female Anopheles mosquitoes is outlined. Important differences between natural immunity and that induced by current candidate vaccines are discussed.
Adrian V S Hill
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Malaria Vaccines: Current Achievements and Path Forward [PDF]
VaccinesMalaria remains a significant global health challenge. Although the recent approval of the liver-stage vaccines RTS, S and R21 marks significant progress in malaria control, challenges remain in achieving long-lasting and broad protection. In this review,
Jiayan Chen +3 more
doaj +2 more sources
Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects [PDF]
Tropical Medicine and Health, 2023 Background The world has made great strides towards beating malaria, although about half of the world population is still exposed to the risk of contracting malaria. Developing an effective malaria vaccine was a huge challenge for medical science.
Amal A. El-Moamly, Mohamed A. El-Sweify
doaj +2 more sources
A roadmap of priority evidence gaps for the co-implementation of malaria vaccines and perennial malaria chemoprevention [PDF]
Malaria JournalProgress in malaria control will rely on deployment and effective targeting of combinations of interventions, including malaria vaccines and perennial malaria chemoprevention (PMC).
Jane Grant +1 more
doaj +2 more sources
Malaria Vaccines and Global Equity: A Scoping Review of Current Progress and Future Directions [PDF]
BiomedicinesThe journey toward a viable malaria vaccine, initiated in 1965, reached a major milestone in 2021 with the WHO’s endorsement of RTS,S/AS01, a recombinant protein-based malaria vaccine.
Rajesh Perumbilavil Kaithamanakallam +10 more
doaj +2 more sources
Whole-sporozoite malaria vaccines: where we are, where we are going [PDF]
EMBO Molecular MedicineThe malaria vaccination landscape has seen significant advancements with the recent endorsement of RTS,S/AS01 and R21/Matrix-M vaccines, which target the pre-erythrocytic stages of Plasmodium falciparum (Pf) infection.
Diana Moita, Miguel Prudêncio
doaj +2 more sources
Vaccines against malaria [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 There is no licenced vaccine against any human parasitic disease and Plasmodium falciparum malaria, a major cause of infectious mortality, presents a great challenge to vaccine developers. This has led to the assessment of a wide variety of approaches to malaria vaccine design and development, assisted by the ...
Adrian V S Hill
exaly +4 more sources