Results 1 to 10 of about 1,223,155 (304)

Synthetic mRNAs Containing Minimalistic Untranslated Regions Are Highly Functional In Vitro and In Vivo

Cells
Synthetic mRNA produced by in vitro transcription (ivt mRNA) is the active pharmaceutical ingredient of approved anti-COVID-19 vaccines and of many drugs under development.
Shahab Mamaghani, Rocco Roberto Penna, Julia Frei, Conrad Wyss, Mark Mellett, Thomas Look, Tobias Weiss, Emmanuella Guenova, Thomas M. Kündig, Severin Lauchli, Steve Pascolo   +10 more
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Modern vaccines and coronavirus infections

Исследования и практика в медицине, 2020
Vaccines represent an outstanding success story in modern medicine and are responsible for a huge reduction in morbidity and mortality worldwide. It is clear that improvements are necessary to enable the development of successful vaccines against some ...
Yu. A. Belikova, Yu. V. Samsonov, E. V. Abakushina   +2 more
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Immunogenicity of multiple antigen peptides containing Plasmodium vivax CS epitopes in BALB/c mice

Memorias do Instituto Oswaldo Cruz, 1994
Multiple antigen peptide systems (MAPs) allow the incorporation of various epitopes in to a single synthetic peptide immunogen. We have characterized the immune response of BALB/c mice to a series of MAPs assembled with different B and T cell epitopes ...
Myriam A. Herrera, Cecilia de Plata, Jhon Mario González, Giampietro Corradin, Socrates Herrera   +4 more
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Synthetic biology-inspired development of live attenuated influenza vaccines

npj Vaccines
Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns.
Qisi Zhang, Jiahui Cheng, Jihuan Hou, Yinlei Su, Le Li, Le Tong, Jing Li, Quan Shen, Zihao Wang, Minqi Wu, Zhen Li, Qikai Wang, Yunfei Zhang, Rui Sun, Longlong Si   +14 more
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Redesigning Protein Function: Towards Synthetic Vaccines and MHC Mimetics

CHIMIA, 1996
Template Assembled Synthetic Proteins (TASP) approach has been applied to mimic 3D-conformations of the hen egg white lysozyme antigen (HEL) and the major histocompatibility complex (MHC) and some of their biological properties.
Gabriele Tuchscherer
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Research progress on emulsion vaccine adjuvants

Heliyon
Vaccination is the most cost-effective method for preventing various infectious diseases. Compared with conventional vaccines, new-generation vaccines, especially recombinant protein or synthetic peptide vaccines, are safer but less immunogenic than ...
Zhuanqing Huang, Hui Gong, Qi Sun, Jinjin Yang, Xiaochuan Yan, Fenghua Xu   +5 more
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Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside

Beilstein Journal of Organic Chemistry, 2019
A series of alkyl thioglycosides and alkyl thiodiglycosides bearing glucose and N-acetylglucosamine residues were prepared by thiol–ene coupling in moderate to good yields (40–85%).
Dimitri Fayolle, Nathalie Berthet, Bastien Doumeche, Olivier Renaudet, Peter Strazewski, Michele Fiore   +5 more
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Cancer vaccines: designing artificial synthetic long peptides to improve presentation of class I and class II T cell epitopes by dendritic cells

OncoImmunology, 2019
There is now a consensus that efficient peptide vaccination against cancer requires that peptides should (i) be exclusively presented by professional APC and (ii) stimulate both CD4 and CD8-specific T cell responses.
Catherine Rabu, Laurie Rangan, Laetitia Florenceau, Agnès Fortun, Maud Charpentier, Emilie Dupré, Léa Paolini, Céline Beauvillain, Estelle Dupel, Jean-Baptiste Latouche, Olivier Adotevi, Nathalie Labarrière, François Lang   +12 more
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Immunogenicity and Protective Effects of an Ag85B Tuberculosis Subunit Vaccine Formulated with Synthetic TLR4 Agonists in BCG-Boosted Mice

Vaccines
Background/Objectives: Tuberculosis (TB) remains a major global health challenge, and the Bacillus Calmette–Guérin (BCG) vaccine has limited efficacy against adult pulmonary disease. Protein subunit vaccines are a promising alternative but require strong
Soo-Min Kim, Jin-Seung Yun, EunJung Shin, Jinhee Lee, You-Jin Kim, Hye-Sook Jeong, Yong Woo Jung, Dokeun Kim   +7 more
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Design and Immune Profile of Multi-Epitope Synthetic Antigen Vaccine Against SARS-CoV-2: An In Silico and In Vivo Approach

Vaccines
Background: The rapid advancement of the pandemic caused by SARS-CoV-2 and its variants reinforced the importance of developing easy-to-edit vaccines with fast production, such as multi-epitope DNA vaccines.
Maria da Conceição Viana Invenção, Larissa Silva de Macêdo, Ingrid Andrêssa de Moura, Lucas Alexandre Barbosa de Oliveira Santos, Benigno Cristofer Flores Espinoza, Samara Sousa de Pinho, Lígia Rosa Sales Leal, Daffany Luana dos Santos, Bianca de França São Marcos, Carolina Elsztein, Georon Ferreira de Sousa, Guilherme Antonio de Souza-Silva, Bárbara Rafaela da Silva Barros, Leonardo Carvalho de Oliveira Cruz, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Cristiane Moutinho Lagos de Melo, Anna Jéssica Duarte Silva, Marcus Vinicius de Aragão Batista, Antonio Carlos de Freitas   +19 more
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