Results 11 to 20 of about 66,703 (260)
Synthetic Messenger RNA-Based Vaccines: From Scorn to Hype
Viruses, 2021 In the race for a vaccine against SARS-CoV-2, the synthetic mRNA format has been shown to be the fastest one and proved to be safe and highly efficient, even at the very low dose of a few µg per injection. The mRNA vaccines are not new: vaccines that are
Steve Pascolo
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Synthetic carbohydrate-based vaccines: challenges and opportunities
Journal of Biomedical Science, 2020 Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial ...
Ravinder Mettu +2 more
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Harnessing synthetic biology for advancing RNA therapeutics and vaccine design
npj Systems Biology and Applications, 2023 Recent global events have drawn into focus the diversity of options for combatting disease across a spectrum of prophylactic and therapeutic approaches. The recent success of the mRNA-based COVID-19 vaccines has paved the way for RNA-based treatments to ...
Blaine A. Pfeifer +4 more
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Vaccines, 2014 Synthetic tumor vaccines have been proven to be promising for cancer immunotherapy. However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements.
Zhi-Hua Huang +6 more
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Synthetic Self-Adjuvanting Glycopeptide Cancer Vaccines
Frontiers in Chemistry, 2015 Due to changes in glycosyltransferase expression during tumorigenesis, the glycoproteins of cancer cells often carry highly truncated carbohydrate chains compared to those on healthy cells.
Richard James Payne +2 more
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New Points of Departure for More Global Influenza Vaccine Use
Vaccines, 2020 Each year, influenza causes a significant acute respiratory disease burden. In addition, influenza pandemics periodically occur. Annual vaccination is the best tool for influenza prevention, but its effectiveness can vary from year to year.
Irina Kiseleva
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Designing synthetic vaccines for HIV [PDF]
Expert Review of Vaccines, 2015 Despite three decades of intensive research efforts, the development of an effective prophylactic vaccine against HIV remains an unrealized goal in the global campaign to contain the HIV/AIDS pandemic. Recent characterization of novel epitopes for inducing broadly neutralizing antibodies has fueled research in the design and synthesis of new, well ...
Alberto Fernández-Tejada +2 more
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Synthetic Vaccines from Tumor-Associated Glycopeptide Antigens
CHIMIA, 2011 The aberrantly glycosylated and extensively over-expressed membrane-bound mucin MUC1 glycoprotein forms a tumor specific epitope on the surface of epithelial cells.
Ulrika Westerlind, Horst Kunz
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Visceral Leishmaniasis: Advancements in vaccine development via classical and molecular approaches
Frontiers in Immunology, 2014 Visceral Leishmaniasis (VL) or kala-azar, a vector-borne protozoan disease, shows endemicity in larger areas of the tropical, subtropical and the Mediterranean countries.
Sumit eJoshi +5 more
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Advances in the design and development of SARS-CoV-2 vaccines
Military Medical Research, 2021 Since the end of 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide.
Xue-Liang Peng +6 more
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