Results 11 to 20 of about 1,223,155 (304)

Synthetic Messenger RNA-Based Vaccines: From Scorn to Hype

Viruses, 2021
In the race for a vaccine against SARS-CoV-2, the synthetic mRNA format has been shown to be the fastest one and proved to be safe and highly efficient, even at the very low dose of a few µg per injection. The mRNA vaccines are not new: vaccines that are
Steve Pascolo
doaj   +2 more sources

Synthetic peptide vaccines

Вопросы вирусологии, 2016
An update on the development and trials of synthetic peptide vaccines is reviewed. The review considers the successful examples of specific protection as a result of immunization with synthetic peptides using various protocols.
O. V. Sergeyev, I. F. Barinsky
doaj   +3 more sources

An Update on mRNA-Based Viral Vaccines

Vaccines, 2021
With the success of COVID-19 vaccines, newly created mRNA vaccines against other infectious diseases are beginning to emerge. Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic ...
Subbiah Jeeva, Ki-Hye Kim, Chong Hyun Shin, Bao-Zhong Wang, Sang-Moo Kang   +4 more
doaj   +2 more sources

Peptide-based synthetic vaccines

Chemical Science, 2016
This review summarise the current stand and future perspective on synthetic peptide-based vaccines.
Skwarczynski, Mariusz, Toth, Istvan
openaire   +7 more sources

PEGylated CuInS2/ZnS quantum dots inhibit neurite outgrowth by downregulating the NGF/p75NTR/MAPK pathway

Ecotoxicology and Environmental Safety, 2021
The widespread application of cadmium-free CuInS2/ZnS QDs has raised great concern regarding their potential toxicity to humans. To date, toxicological data related to CuInS2/ZnS QDs are scarce.
Zhiwen Yang, Wenyi Zou, Yongning Pan, Ken-Tye Yong, Li Li, Xiaomei Wang, Dongmeng Liu, Tingting Chen, Dahui Xue, Guimiao Lin   +9 more
doaj   +1 more source

Systematic evaluation of CdSe/ZnS quantum dots toxicity on the reproduction and offspring health in male BALB/c mice

Ecotoxicology and Environmental Safety, 2021
Increased applications of quantum dots (QDs) in the biomedical field have aroused attention for their potential toxicological effects. Although numerous studies have been carried out on the toxicity of QDs, their effects on reproductive and development ...
Li Li, Xiaotan Lin, Tingting Chen, Kan Liu, Yajing Chen, Zhiwen Yang, Dongmeng Liu, Gaixia Xu, Xiaomei Wang, Guimiao Lin   +9 more
doaj   +1 more source

Chemical and Synthetic Biology Approaches for Cancer Vaccine Development

Molecules, 2022
Cancer vaccines have been considered promising therapeutic strategies and are often constructed from whole cells, attenuated pathogens, carbohydrates, peptides, nucleic acids, etc.
Farzana Hossain, Shruthi Kandalai, Xiaozhuang Zhou, Nan Zhang, Qingfei Zheng   +4 more
doaj   +1 more source

Glyceraldehyde-3-phosphate dehydrogenase common peptides of listeria monocytogenes, mycobacterium marinum and streptococcus pneumoniae as universal vaccines [PDF]

, 2021
Universal vaccines can be prepared with antigens common to different pathogens. In this regard, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a common virulence factor among pathogenic bacteria of the genera Listeria, Mycobacterium and ...
Del Molino-Bernal, I. Concepción Pérez, Torres-Rodriguez, Paula, Calvo-Montes, Jorge, David Salcines-Cuevas, Pérez Del Molino-Bernal, Concepción, Ricardo Calderón-Gonzalez, Manuel Fresno, Álvarez-Domínguez, Carmen, Teran-Navarro, Héctor, Fresno, Manuel, Raquel Tobes, Molino-Bernal, I Concepción Pérez Del, Paula Torres-Rodriguez, Carmen Alvarez-Dominguez, I. Concepción Pérez Del Molino-Bernal, Salcines-Cuevas, David, Fresno Escudero, Manuel, Pérez Del Molino Bernal, I. Concepción, Hector Terán-Navarro, Yañez-Diaz, Sonsoles, Jorge Calvo-Montes, Sonsoles Yañez-Diaz, Calderón-González, Ricardo, Tobes, Raquel   +23 more
core   +1 more source

Cytotoxicity and Immune Dysfunction of Dendritic Cells Caused by Graphene Oxide

Frontiers in Pharmacology, 2020
Graphene, known as “black gold”, has important applications in various fields. In previous studies, it has been proved that graphene oxide (GO) which is a derivative of graphene has low toxicity.
Zhiwen Yang, Yongning Pan, Tingting Chen, Li Li, Wenyi Zou, Dongmeng Liu, Dahui Xue, Xiaomei Wang, Guimiao Lin   +8 more
doaj   +1 more source

A Chemically Defined Four-Component Self-Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity. [PDF]

Adv Sci (Weinh)
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Ming W, Zhang R, Li X, Li G, Niu Y, Yang D, Luo X, Liao J, Liu Z, Liao G.   +9 more
europepmc   +2 more sources