Results 41 to 50 of about 79,327 (229)
Nature Communications, 2018 Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria.
Alvaro Baeza Garcia +13 more
doaj +1 more source
A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum [PDF]
, 2016 Background: The malaria vaccine candidate RTS, S/AS01 (GSK Vaccines) induces high IgG concentration against the circumsporozoite protein (CSP) of Plasmodium falciparum.
Clement, Frédéric +7 more
core +4 more sources
Malaria vaccine development [PDF]
Clinical Microbiology Reviews, 1994 The malaria parasite life cycle presents several targets for attack, but these different parts of the life cycle are susceptible to different types of host immune response. For example, the sporozoite is most sensitive to immune antibody, while liver stage parasites can be eliminated by cytotoxic T lymphocytes. Attachment of merozoites to erythrocytes,
T R, Jones, S L, Hoffman
openaire +2 more sources
Malaria infections do not compromise vaccine-induced immunity against tuberculosis in mice.
PLoS ONE, 2011 BackgroundGiven the considerable geographic overlap in the endemic regions for malaria and tuberculosis, it is probable that co-infections with Mycobacterium tuberculosis and Plasmodium species are prevalent.
Marcela Parra +9 more
doaj +1 more source
Antibody and B cell responses to Plasmodium sporozoites [PDF]
, 2014 Antibodies are capable of blocking infection of the liver by Plasmodium sporozoites. Accordingly the induction of anti-sporozoite antibodies is a major aim of various vaccine approaches to malaria.
Cockburn, Ian A. +2 more
core +2 more sources
The rise of companies from emerging markets in global health governance: opportunities and challenges [PDF]
, 2014 The article analyses the involvement of pharmaceutical companies from emerging markets in global health governance. It finds that they play a central role as low-cost suppliers of medicines and vaccines and, increasingly, new technologies.
ANNE ROEMER-MAHLER +23 more
core +1 more source
The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination [PDF]
, 2018 Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T cells play a central role in all adaptive immune responses.
Gray, Joshua I. +2 more
core +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
npj VaccinesVaccines to the Plasmodium falciparum reticulocyte binding-like protein homologue 5 (PfRH5) target the blood-stage of the parasite life cycle. PfRH5 has the potential to trigger the production of strain-transcendent antibodies and has proven its efficacy
Laty G. Thiam +18 more
doaj +1 more source
Malaria vaccines and their potential role in the elimination of malaria
Malaria Journal, 2008 Research on malaria vaccines is currently directed primarily towards the development of vaccines that prevent clinical malaria. Malaria elimination, now being considered seriously in some epidemiological situations, requires a different vaccine strategy,
Greenwood Brian M, Targett Geoffrey A
doaj +1 more source