Results 41 to 50 of about 36,581 (138)
npj Vaccines, 2021 Despite considerable effort, malaria remains a major public health burden. Malaria is caused by five Plasmodium species and is transmitted to humans via the female Anopheles mosquito. The development of malaria vaccines against the liver and blood stages
Yacob Keleta +3 more
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Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives
Precision Medical Sciences, EarlyView.Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
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Small Methods, EarlyView.Deep‐Ultraviolet Resonance Raman (DUVRR) spectroscopy is introduced as a label‐free, non‐invasive analytical workflow for the biochemical fingerprinting of enveloped viruses. By integrating bottom‐up stoichiometric reconstruction with top‐down biochemical extraction, this strategy accurately disentangles complex viral compositions in physiological‐like
Denis Rajnovic +8 more
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Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells
Frontiers in Immunology, 2019 Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition of immunity and the efficacy of vaccines.
Xi Zen Yap +11 more
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A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA
Acta Paediatrica, EarlyView.ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Tobias Alfvén, Tania Reza, Alieu Sowe
wiley +1 more source
An open source business model for malaria. [PDF]
PLoS ONE, 2015 Greater investment is required in developing new drugs and vaccines against malaria in order to eradicate malaria. These precious funds must be carefully managed to achieve the greatest impact.
Christine Årdal, John-Arne Røttingen
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Health Research Funders and Justice: Obligations to Coordinate and Counterbalance
Bioethics, EarlyView.ABSTRACT Government health research funders are frequently criticized on the grounds that their distribution of resources fails to reflect a population's disease burden. These critiques do not take into account what other research funders are doing. In this paper, I argue that this is a mistake.
Joseph Millum
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Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
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Assessment of Antibodies Induced by Multivalent Transmission-Blocking Malaria Vaccines
Frontiers in Immunology, 2018 A malaria transmission-blocking vaccine would be a critical tool in achieving malaria elimination and eradication. By using chimpanzee adenovirus serotype 63 and modified vaccinia virus Ankara viral vectored vaccines, we investigated whether ...
Vinay Menon +8 more
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Insect Molecular Biology, EarlyView.Aedes aegypti females were significantly repelled by both volatile DEET and citronella oil in comparison to control (ethanol‐exposed) mosquitoes. Global gene expression changes were largest in the mosquito mouthparts, with notable downregulation of the three subunits comprising the mosquito CO2 receptor (Gr1, 2 and 3).
Ivan Drahun +3 more
wiley +1 more source