Results 51 to 60 of about 41,093 (223)

Decentralisation of the Healthcare Systems and the Functioning of Public Health Programmes in Single‐Party States: A Systematic Review

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Introduction Decentralisation is the transfer of authority from central to local governments, involving shared responsibilities in planning, management, and decision‐making. In public health, decentralisation might help improve service delivery by allowing local authorities to tailor interventions to the specific needs of diverse ...
Phonevilay Viphonephom, Ho Van Hoa, Sengchanh Kounnavong, Daniel Reinharz   +3 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Protective CD8+ T lymphocytes in primates immunized with malaria sporozoites. [PDF]

PLoS ONE, 2012
Live attenuated malaria vaccines are more potent than the recombinant protein, bacterial or viral platform vaccines that have been tested, and an attenuated sporozoite vaccine against falciparum malaria is being developed for humans.
Walter R Weiss, Chengyong George Jiang
doaj   +1 more source

A Critical Review on Human Malaria and Schistosomiasis Vaccines: Current State, Recent Advancements, and Developments

Vaccines, 2023
Malaria and schistosomiasis are two major parasitic diseases that remain leading causes of morbidity and mortality worldwide. Co-infections of these two parasites are common in the tropics, where both diseases are endemic.
Arif Jamal Siddiqui, Jyoti Bhardwaj, Juhi Saxena, Sadaf Jahan, Mejdi Snoussi, Fevzi Bardakci, Riadh Badraoui, Mohd Adnan   +7 more
doaj   +1 more source

Malaria vaccine developments

The Lancet, 2004
Large gains in the reduction of malaria mortality in the early 20th century were lost in subsequent decades. Malaria now kills 2-3 million people yearly. Implementation of malaria control technologies such as insecticide-treated bednets and chemotherapy could reduce mortality substantially, but an effective malaria vaccine is also needed.
Moorthy, V, Good, M, Hill, A
openaire   +3 more sources

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial. [PDF]

, 2011
BACKGROUND\ud \ud The RTS,S/AS01(E) candidate malaria vaccine is being developed for immunisation of infants in Africa through the expanded programme on immunisation (EPI).
Abdulla, Salim, Sillman, Marla, Tanner, M., Osei-Kwakye, Kingsley, Vekemans, J., Solange Soulanoudjingar, Apanga, Stephen, Adjei, George, Agnandji, S., Grace Mwangoka, Jose F Fernandes, Leach, Amanda, Issifou, Saadou, Owusu-Agyei S.,, Didier Lapierre, Lapierre, Didier, Chandramohan, Daniel, Dosoo, D., Dubois, Marie-Claude, Boahen, Owusu, Joe Cohen, Greenwood, B., Kayan, K., Lyimo, John, Apanga, S., Boahen, O., Kwaku Poku Asante, Loucq, Christian, Maria Paricek, Salim Abdulla, Asante, Kwaku Poku, Carter, T., Owusu-Agyei, Seth, Marcel Tanner, Kremsner, Peter, Marie-Claude Dubois, Evans Kwara, Marc Lievens, Kayan, Kingsley, Asante-Poku A.,, Owusu, R., Jongert, Erik, Vansadia, P., Tigani Madi, Nahya Salim, Kingsley Kayan, Leach, A., Lievens, Marc, Madi, Tigani, Chikawe, Maria, Paricek, Maria, Savarese, B., Stephen Apanga, Amanda Leach, Agnandji, Selidji, Vansadia, Preeti, Owusu, Ruth, Daniel Chandramohan, Fernandes, Jose F, Jongert, E., Salim, N., Cohen, J., Abdulla, S., Erik Jongert, Christian Loucq, Kwara, Evans, George Adjei, Preeti Vansadia, Möller, Tina, Mwangoka, G., John Lyimo, Soulanoudjingar, Solange, Greenwood, Brian, Hounkpatin, A. B., Marla Sillman, Cohen, Joe, Saadou Issifou, Issifou, S., Osei-Kwakye K.,, Owusu Boahen, Barbara Savarese, Maria Chikawe, Kwara, E., Moller, T., Hounkpatin, Aurore B, Lell, Bertrand, Carter, Terrell, Loucq, C., Shomari, Mwanajaa, Kremsner, P., Rose Minja, Kingsley Osei-Kwakye, Tina Möller, Minja, Rose, Selidji Agnandji, Lyimo, J., Sillman, M., David Dosoo, Mwanajaa Shomari, Chikawe, M., Paricek, M., Ruth Owusu, Aurore B Hounkpatin, Minja, R., Lievens, M., Brian Greenwood, Vekemans, Johan, Tanner, Marcel, Peter Kremsner, Fernandes, J. F., Dosoo, David, Savarese, Barbara, Seth Owusu-Agyei, Mwangoka, Grace, Lapierre, D., Bertrand Lell, Madi, T., Shomari, M., Terrell Carter, Salim, Nahya, Dubois, M. C., Soulanoudjingar, S., Adjei, G., Lell, B., Chandramohan, D., Johan Vekemans   +125 more
core   +1 more source

Genetic diversity in the Plasmodium falciparum next-generation blood stage vaccine candidate antigen PfCyRPA in Senegal

Scientific Reports
The Plasmodium falciparum cysteine-rich protective antigen (PfCyRPA) is a promising target as a next-generation blood-stage malaria vaccine and together with PCRCR complex members, the reticulocyte binding-like homologous protein 5 (PfRh5) and the Rh5 ...
Aboubacar Ba, Laty Gaye Thiam, Mariama Nicole Pouye, Yicheng Guo, Saurabh D. Patel, Seynabou Diouf Sene, Fatoumata Diallo, Rebecca Li, Awa Cisse, Noemi Guerra, Safia Laqqa, Khadidiatou Mangou, Adam J. Moore, Bacary Djilocalisse Sadio, Jean Louis Abdourahim Ndiaye, Alassane Mbengue, Ines Vigan-Womas, Zizhang Sheng, Lawrence Shapiro, Amy K. Bei   +19 more
doaj   +1 more source

Vaccines for preventing malaria [PDF]

Cochrane Database of Systematic Reviews, 2003
Despite continued efforts to control the disease, malaria remains a major health problem in many regions of the world, especially sub-Saharan Africa, and new ways to control or eradicate the disease are urgently needed. Two types of vaccine, SPf66 vaccine against the asexual stages, and NANP vaccines against the sporozoite stages of the Plasmodium ...
P, Graves, H, Gelband
openaire   +3 more sources

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source