Results 61 to 70 of about 36,581 (138)

Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine

Malaria Journal, 2017
In many parts of the African Sahel and sub-Sahel, where malaria remains a major cause of mortality and morbidity, transmission of the infection is highly seasonal.
Brian Greenwood, Alassane Dicko, Issaka Sagara, Issaka Zongo, Halidou Tinto, Matthew Cairns, Irene Kuepfer, Paul Milligan, Jean-Bosco Ouedraogo, Ogobara Doumbo, Daniel Chandramohan   +10 more
doaj   +1 more source

Dual Burden of Conflicts and Healthcare Collapse in the Democratic Republic of Congo: A Call for Action

Public Health Challenges, Volume 5, Issue 3, September 2026.
The dual burden of conflict and healthcare attacks in the DRC has led to system collapse, resulting in the destruction of facilities, massive displacement, and the resurgence of deadly outbreaks. Urgent global action and coordinated, sustained investments are imperative to protect health services and prevent further catastrophe.
Emile Cyubahiro, Darius Benimana
wiley   +1 more source

Identification of a growth-inhibitory epitope in PfRipr5, a malaria vaccine candidate against Plasmodium falciparum

Frontiers in Immunology
BackgroundThe Plasmodium falciparum Rh5-interacting protein (PfRipr) is a key component of the pentameric PTRAMP-CSS-PfRipr-CyRPA-RH5 (PCRCR) complex, which is essential for erythrocyte invasion. Antibodies against PfRipr can inhibit parasite growth, but
Hikaru Nagaoka, Akihisa Fukushima, Takafumi Tsuboi, Eizo Takashima   +3 more
doaj   +1 more source

Mass campaigns combining antimalarial drugs and anti-infective vaccines as seasonal interventions for malaria control, elimination and prevention of resurgence: a modelling study

BMC Infectious Diseases, 2019
Background The only licensed malaria vaccine, RTS,S/AS01, has been developed for morbidity-control in young children. The potential impact on transmission of deploying such anti-infective vaccines to wider age ranges, possibly with co-administration of ...
Flavia Camponovo, Chris F. Ockenhouse, Cynthia Lee, Melissa A. Penny   +3 more
doaj   +1 more source

A 5‐Year Retrospective Morbidity Profile of School‐Aged Children at Ho Polyclinic, Volta Region, Ghana: Skin Conditions, Malaria, and Respiratory Illnesses as Leading Causes (2018–2022)

Public Health Challenges, Volume 5, Issue 3, September 2026.
Analysis of 10,428 outpatient consultations among school‐aged children attending Ho Polyclinic, Ghana (2018–2022), showed that three conditions accounted for 77.4% of all morbidity: skin conditions (38.3%), malaria (23.0%), and respiratory conditions (16.1%).
Anthoinette Adesope Ekuban, Frank Baiden
wiley   +1 more source

Determinants of Severe Acute Malnutrition Among Children Aged 6–23 Months Attending Public Hospitals in the Benadir Region, Somalia: An Unmatched Case–Control Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Severe acute malnutrition (SAM) remains a leading cause of morbidity and mortality among children under 2 years in Somalia. This study aimed to identify determinants of SAM using a hospital‐based unmatched case–control design.
Muna Hassan Warsame, Sade Bashir Hassan, Jamal Hassan Mohamoud, Ahmed Mahad Sheikh Mohamed, Mohamed Hussein Adam, Bashiru Garba, Mohamed Adam Mahamud   +6 more
wiley   +1 more source

Targeting mucosal immunity in malaria control: the underexplored role of IgA

Frontiers in Malaria
Malaria remains a global health crisis, causing an estimated 263 million cases and 597,000 deaths in 2023. Current measures—including insecticide-treated nets, ACTs, and the RTS,S vaccine—have stalled in reducing mortality, highlighting the need for ...
Haruna Muwonge, Haruna Muwonge, Isaac Ssewanyana, Adoke Yeka, Pauline Byakika-Kibwika, Pauline Byakika-Kibwika   +5 more
doaj   +1 more source

Antimicrobial Stewardship, Laboratory Surveillance, and Quality Management in Africa: A Narrative Review of Challenges and Opportunities for Integrated AMR Control

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Introduction Antimicrobial resistance (AMR) is a growing public health threat that disproportionately affects African countries due to high infectious disease burdens, widespread antimicrobial misuse, weak health systems, inadequate diagnostic capacity, and fragmented surveillance infrastructure.
Ameh Wisdom Owoicho, Majani Edward
wiley   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Pocket restraints guided by B‐cell epitope prediction improve Chai‐1 antibody–antigen structure modeling

Protein Science, Volume 35, Issue 8, August 2026.
Abstract The accurate prediction of antibody–antigen (AbAg) complexes is a key challenge for computational immunology, with applications in therapeutic antibody design and diagnostics. Current deep learning methods have the potential to generate high‐confidence AbAg structures.
Joakim Nøddeskov Clifford, Morten Nielsen   +1 more
wiley   +1 more source