Results 101 to 110 of about 532,559 (334)

Assessing the community-level impact of group antenatal care on uptake of intermittent preventive treatment for malaria in pregnancy in Atlantique Department, Benin, 2021–2023: a cluster randomized controlled trial

open access: yesMalaria Journal
Background In 2023, an estimated 36 million pregnancies occurred in malaria endemic sub-Saharan Africa, but only 44% received the WHO recommended ≥ 3 doses of intermittent preventive treatment (IPTp3).
Julie R. Gutman   +17 more
doaj   +1 more source

Malaria [PDF]

open access: yesBMJ, 2011
Mirza, D. M., Hashim, M. J., Sheikh, A.
openaire   +3 more sources

Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin

open access: yesCytoskeleton, EarlyView.
ABSTRACT The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore‐associated factor.
Franziska Hentzschel   +2 more
wiley   +1 more source

C1′‐Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium Falciparum 6‐Oxopurine Phosphoribosyltransferase

open access: yesChemMedChem, EarlyView.
Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych   +11 more
wiley   +1 more source

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria

open access: yesMalaria Journal, 2018
Over the last 15 years, the majority of malaria drug discovery and development efforts have focused on new molecules and regimens to treat patients with uncomplicated or severe disease.
Fiona Macintyre   +11 more
doaj   +1 more source

The Reactivity of α‐Fluorinated Mono‐ and Diketones Uncovers their Potential as Electrophilic Warheads for Reversible Covalent Drugs

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
The potential of fluorinated mono‐ and diketones as electrophilic warheads for reversible covalent drugs is described by studying their equilibria reactions with the protected nucleophilic amino acids serine, cysteine and lysine. Fluorinated diketones (FDKs) are electrophilic moieties holding unique molecular properties that make them potential ...
Yossi Zafrani   +5 more
wiley   +1 more source

Malaria [PDF]

open access: yesJAMA, 2022
Walter, Kristin, John, Chandy C.
openaire   +2 more sources

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