Results 101 to 110 of about 532,559 (334)
Background In 2023, an estimated 36 million pregnancies occurred in malaria endemic sub-Saharan Africa, but only 44% received the WHO recommended ≥ 3 doses of intermittent preventive treatment (IPTp3).
Julie R. Gutman+17 more
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Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin
ABSTRACT The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore‐associated factor.
Franziska Hentzschel+2 more
wiley +1 more source
Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych+11 more
wiley +1 more source
Over the last 15 years, the majority of malaria drug discovery and development efforts have focused on new molecules and regimens to treat patients with uncomplicated or severe disease.
Fiona Macintyre+11 more
doaj +1 more source
A CONTRIBUTION TO THE MICROSCOPICAL HISTOLOGY OF MALARIA, [PDF]
LeonardS. Dudgeon, Cecil Clarke
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The potential of fluorinated mono‐ and diketones as electrophilic warheads for reversible covalent drugs is described by studying their equilibria reactions with the protected nucleophilic amino acids serine, cysteine and lysine. Fluorinated diketones (FDKs) are electrophilic moieties holding unique molecular properties that make them potential ...
Yossi Zafrani+5 more
wiley +1 more source
SURGEON-MAJOR RONALD ROSS'S RECENT INVESTIGATIONS on the MOSQUITO-MALARIA THEORY [PDF]
P. Manson
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