Results 111 to 120 of about 869,297 (419)

Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia [PDF]

, 2017
Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown.
Hodges, James S., Hume, Heather A., John, Chandy C., Kasirye, Phillip, Lane, Adam, Latham, Teresa S., Ndugwa, Christopher M., Opoka, Robert O., Ware, Russell E.   +8 more
core   +2 more sources

The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs

Advanced NanoBiomed Research, EarlyView.
Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng   +11 more
wiley   +1 more source

From efficacy to effectiveness: a comprehensive framework for monitoring, evaluating and optimizing seasonal malaria chemoprevention programmes

Malaria Journal
Background Seasonal Malaria Chemoprevention (SMC) is a highly effective intervention for preventing malaria, particularly in areas with highly seasonal transmission.
Monica Anna de Cola, Elisabeth G. Chestnutt, Sol Richardson, Matthieu Baudry, Chuks Nnaji, Taiwo Ibinaiye, Azoukalné Moukénet, Kunle Rotimi, Benoît Sawadogo, Joshua Okafor, Cheick Saïd Compaoré, Chibuzo Oguoma, Christian Rassi, Arantxa Roca-Feltrer   +13 more
doaj   +1 more source

Insecticide resistance patterns in Uganda and the effect of indoor residual spraying with bendiocarb on kdr L1014S frequencies in Anopheles gambiae s.s.

Malaria Journal, 2017
Background Resistance of malaria vectors to pyrethroid insecticides has been attributed to selection pressure from long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), and the use of chemicals in agriculture.
Tarekegn A. Abeku, Michelle E. H. Helinski, Matthew J. Kirby, James Ssekitooleko, Chris Bass, Irene Kyomuhangi, Michael Okia, Godfrey Magumba, Sylvia R. Meek   +8 more
doaj   +1 more source

Comparison of three diagnostic methods (microscopy, RDT, and PCR) for the detection of malaria parasites in representative samples from Equatorial Guinea

Malaria Journal, 2018
Malaria in Equatorial Guinea remains a major public health problem. The country is a holo-endemic area with a year-round transmission pattern. In 2016, the prevalence of malaria was 12.09% and malaria caused 15% of deaths among children under 5 years. In
P. Berzosa, A. de Lucio, M. Romay-Barja, Z. Herrador, V. González, L. García, A. Fernández-Martínez, M. Santana-Morales, P. Ncogo, B. Valladares, M. Riloha, A. Benito   +11 more
semanticscholar   +1 more source

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

Machine learning using convolutional neural networks for SERS analysis of biomarkers in medical diagnostics

Journal of Raman Spectroscopy, Volume 53, Issue 12, Page 2044-2057, December 2022., 2022
We compared the performances of spectral decomposition, support vector regression, random forest regression, partial least squares regression, and convolutional neural network for SERS “spectral unmixing” from a multiplexed mixture of 7 SERS‐active “nanorattles” loaded with different dyes for mRNA biomarker detection.
Joy Qiaoyi Li, Priya Vohra Dukes, Walter Lee, Michael Sarkis, Tuan Vo‐Dinh   +4 more
wiley   +1 more source

Delivery of seasonal malaria chemoprevention with enhanced infection prevention and control measures during the COVID-19 pandemic in Nigeria, Burkina Faso and Chad: a cross-sectional study

Malaria Journal, 2022
Background Seasonal malaria chemoprevention (SMC) is a WHO-recommended intervention for children aged 3–59 months living in areas of high malaria transmission to provide protection against malaria during the rainy season.
Charlotte Ward, Abimbola Phillips, Olusola Oresanya, Gloria Olisenekwu, Ekundayo Arogunade, Azoukalné Moukénet, Honoré Beakgoubé, Vincent De Paul Allambademel, Cheick Saïd Compaoré, Adama Traoré, Jean-Bosco Ouedraogo, Yves Daniel Compaoré, Issaka Zongo, Laura Donovan, Monica Anna Decola, Helen Smith, Kevin Baker   +16 more
doaj   +1 more source

Reshaping the use of digital tools to fight malaria [PDF]

arXiv, 2018
In this extended abstract we present our approach to marshal digital tools in the fight against malaria. We describe our scalable infrastructure which leverages abstractions to support effective deployment of existing computational models and their associated data.
arxiv  

Malaria Risk Mapping Using Routine Health System Incidence Data in Zambia [PDF]

arXiv, 2021
Improvements to Zambia's malaria surveillance system allow better monitoring of incidence and targetting of responses at refined spatial scales. As transmission decreases, understanding heterogeneity in risk at fine spatial scales becomes increasingly important. However, there are challenges in using health system data for high-resolution risk mapping:
arxiv