Results 191 to 200 of about 1,691,364 (322)

Quantitative Prediction of Human Pharmacokinetics for Fc‐Engineered Therapeutic Monoclonal Antibodies With Increased FcRn Binding Mutations After Subcutaneous Injection

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Fc‐engineered antibodies (mAbs) enhancing FcRn binding have rapidly expanded in drug discovery and development. Although an approach exists for predicting the pharmacokinetics of Fc‐engineered mAbs after intravenous injections in humans, no methodology has been established for predicting pharmacokinetics after subcutaneous injections.
Kenta Haraya, Taichi Kuramochi
wiley   +1 more source

Elimination of malaria: halfway there [PDF]

Transactions of The Royal Society of Tropical Medicine and Hygiene, 2017
openaire   +2 more sources

Malaria incidence in Myanmar 2005–2014: steady but fragile progress towards elimination [PDF]

, 2016
Thet Thet Mu, Aye Aye Sein, Tint Tint Kyi, Myo Min, Ne Myo Aung, Nicholas M. Anstey, Myat Phone Kyaw, Chit Soe, Mar Mar Kyi, Josh Hanson   +9 more
openalex   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, Volume 600, Issue 2, Page 239-250, January 2026.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

MOESM4 of Common asymptomatic and submicroscopic malaria infections in Western Thailand revealed in longitudinal molecular and serological studies: a challenge to malaria elimination

, 2019
Elisabeth Baum, Jetsumon Sattabongkot, Jeeraphat Sirichaisinthop, Kirakorn Kiattibutr, Aarti Jain, Omid Taghavian, Ming‐Chieh Lee, D. Huw Davies, Liwang Cui, Philip L. Felgner, Guiyun Yan   +10 more
openalex   +1 more source

Novel strategies lead to pre-elimination of malaria in previously high-risk areas in Suriname, South America [PDF]

, 2012
Hélène Hiwat, Loretta Hardjopawiro, Willem Takken, Leopoldo Villegas   +3 more
openalex   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Correction: Malaria elimination and the need for intensive inter-country cooperation: a critical evaluation of regional technical co-operation in Southern Africa

Malaria Journal
Chadwick H. Sikaala, Bongani Dlamini, Alphart Lungu, Phelele Fakudze, Mukosha Chisenga, Chishala Lukwesa Siame, Nyasha Mwendera, Dumisani Shaba, John M. Chimumbwa, Immo Kleinschmidt   +9 more
doaj   +1 more source

Malaria elimination practices in China from the perspective of health system and social development. [PDF]

Infect Dis Poverty
Song X, Liu Z, Li N, Chen L, Liu M, Liu J, Zhang Y, Wang M, Ren M.   +8 more
europepmc   +1 more source

The challenge of artemisinin resistance can only be met by eliminating Plasmodium falciparum malaria across the Greater Mekong subregion [PDF]

, 2014
Cara Smith Gueye, Gretchen Newby, Jimee Hwang, Allison Phillips, Maxine Whittaker, John R. MacArthur, Roly Gosling, Richard Feachem   +7 more
openalex   +1 more source