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Malaria Prevention: Progress to Date. [PDF]

Drugs
Chemoprophylaxis (in travellers) and seasonal chemoprophylaxis and preventive treatment (in endemic areas) are important but not exclusive elements of malaria prevention, which hinges on vector repelling in travellers and more comprehensive vector control measures in endemic areas.
Grobusch MP, Schnyder JL, Schlagenhauf P, de Jong HK, Hanscheid T.   +4 more
europepmc   +3 more sources

HRP2 and HRP3 cross-reactivity and implications for HRP2-based RDT use in regions with Plasmodium falciparum hrp2 gene deletions

Malaria Journal, 2021
Background The Plasmodium falciparum antigen histidine rich protein 2 (HRP2) is a preferred target for malaria rapid diagnostic tests (RDTs) because of its abundant production by the parasite and thermal stability.
Amy Kong, Scott A. Wilson, Yong Ah, Douglas Nace, Eric Rogier, Michael Aidoo   +5 more
doaj   +1 more source

Purification of native histidine-rich protein 2 (nHRP2) from Plasmodium falciparum culture supernatant, infected RBCs, and parasite lysate

Malaria Journal, 2021
Background Despite the widespread use of histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDTs), purified native HRP2 antigen is not standardly used in research applications or assessment of RDTs used in the field.
Balwan Singh, Jessica N. McCaffery, Amy Kong, Yong Ah, Scott Wilson, Sayan Chatterjee, Deepak Tomar, Michael Aidoo, Venkatachalam Udhayakumar, Eric Rogier   +9 more
doaj   +1 more source

Vaccines for preventing malaria [PDF]

Cochrane Database of Systematic Reviews, 2003
Despite continued efforts to control the disease, malaria remains a major health problem in many regions of the world, especially sub-Saharan Africa, and new ways to control or eradicate the disease are urgently needed. Two types of vaccine, SPf66 vaccine against the asexual stages, and NANP vaccines against the sporozoite stages of the Plasmodium ...
P, Graves, H, Gelband
openaire   +3 more sources

Portable and cost-effective genetic detection and characterization of Plasmodium falciparum hrp2 using the MinION sequencer

Scientific Reports, 2023
The prevalence of Plasmodium falciparum hrp2 (pfhrp2)-deleted parasites threatens the efficacy of the most used and sensitive malaria rapid diagnostic tests and highlights the need for continued surveillance for this gene deletion.
Susanna Sabin, Sophie Jones, Dhruviben Patel, Gireesh Subramaniam, Julia Kelley, Michael Aidoo, Eldin Talundzic   +6 more
doaj   +1 more source

Assessment of molecular markers of anti-malarial drug resistance among children participating in a therapeutic efficacy study in western Kenya

Malaria Journal, 2020
Background Anti-malarial drug resistance remains a major threat to global malaria control efforts. In Africa, Plasmodium falciparum remains susceptible to artemisinin-based combination therapy (ACT), but the emergence of resistant parasites in multiple ...
Winnie Chebore, Zhiyong Zhou, Nelli Westercamp, Kephas Otieno, Ya Ping Shi, Sheila B. Sergent, Kelsey Anne Rondini, Samaly Souza Svigel, Benard Guyah, Venkatachalam Udhayakumar, Eric S. Halsey, Aaron M. Samuels, Simon Kariuki   +12 more
doaj   +1 more source

Investigation of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions and performance of a rapid diagnostic test for identifying asymptomatic malaria infection in northern Ethiopia, 2015

Malaria Journal, 2022
Background Rapid diagnostic tests (RDTs) are widely used for malaria diagnosis of both symptomatic and asymptomatic infections. Although RDTs are a reliable and practical diagnostic tool, the sensitivity of histidine-rich protein 2 (HRP2)-based RDTs can ...
Colleen M. Leonard, Ashenafi Assefa, Jessica N. McCaffery, Camelia Herman, Mateusz Plucinski, Heven Sime, Hussein Mohammed, Amha Kebede, Hiwot Solomon, Mebrahtom Haile, Matt Murphy, Jimee Hwang, Eric Rogier   +12 more
doaj   +1 more source

Prevention of Malaria in Children [PDF]

Clinical Infectious Diseases, 2002
Although malaria kills approximately 1 million children each year, preventive measures can be effective in limiting the mortality and morbidity associated with malaria. Mosquito bites can be avoided by use of appropriate environmental control and use of protective clothing, bed nets, repellents, and insecticide.
Philip R, Fischer, Ralf, Bialek
openaire   +2 more sources

Low prevalence of highly sulfadoxine‐resistant dihydropteroate synthase alleles in Plasmodium falciparum isolates in Benin

Malaria Journal, 2021
Background In 2004, in response to high levels of treatment failure associated with sulfadoxine-pyrimethamine (SP) resistance, Benin changed its first-line malaria treatment from SP to artemisinin-based combination therapy for treatment of uncomplicated ...
Samaly Souza Svigel, Adicath Adeothy, Augustin Kpemasse, Ernest Houngbo, Antoine Sianou, Ramani Saliou, Monica E. Patton, Fortune Dagnon, Eric S. Halsey, Alexis Tchevoede, Venkatachalam Udhayakumar, Naomi W. Lucchi   +11 more
doaj   +1 more source

Multiplex malaria antigen detection by bead-based assay and molecular confirmation by PCR shows no evidence of Pfhrp2 and Pfhrp3 deletion in Haiti

Malaria Journal, 2019
Background The Plasmodium falciparum parasite is the only human malaria that produces the histidine-rich protein 2 and 3 (HRP2/3) antigens. Currently, HRP2/3 are widely used in malaria rapid diagnostic tests (RDTs), but several global reports have ...
Camelia Herman, Curtis S. Huber, Sophie Jones, Laura Steinhardt, Mateusz M. Plucinski, Jean F. Lemoine, Michelle Chang, John W. Barnwell, Venkatachalam Udhayakumar, Eric Rogier   +9 more
doaj   +1 more source