Results 41 to 50 of about 64,623 (227)

Mechanism of complement inhibition by a mosquito protein revealed through cryo-EM

Communications Biology
Salivary complement inhibitors occur in many of the blood feeding arthropod species responsible for transmission of pathogens. During feeding, these inhibitors prevent the production of proinflammatory anaphylatoxins, which may interfere with feeding ...
John F. Andersen, Haotian Lei, Ethan C. Strayer, Van Pham, José M. C. Ribeiro   +4 more
doaj   +1 more source

A Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation

American Journal of Hematology, EarlyView.
ABSTRACT Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part ...
Marilou Tetard, Tianjian Lin, Nana A. Peterson, Rebekah C. Gullberg, Yann Le Guen, Jasmine Moshiri, John G. Doench, Elizabeth S. Egan   +7 more
wiley   +1 more source

Effectiveness of 24-h mobile reporting tool during a malaria outbreak in Mpumalanga Province, South Africa

Malaria Journal, 2019
Background As surveillance is a key strategy for malaria elimination in South Africa, ensuring strong surveillance systems is a National Department of Health priority.
Craig Davies, Rebecca Graffy, Mbavhalelo Shandukani, Ednah Baloyi, Laura Gast, Gerdalize Kok, Frans Mbokazi, Alpheus Zita, Mandla Zwane, Ray Magagula, Aaron Mabuza, Wayne Ramkrishna, Natashia Morris, Jacqueline Porteous, George Shirreff, Lucille Blumberg, Eunice Misiani, Devanand Moonasar   +17 more
doaj   +1 more source

Genome sequence, transcriptome, and annotation of rodent malaria parasite Plasmodium yoelii nigeriensis N67

BMC Genomics, 2021
Background Rodent malaria parasites are important models for studying host-malaria parasite interactions such as host immune response, mechanisms of parasite evasion of host killing, and vaccine development.
Cui Zhang, Cihan Oguz, Sue Huse, Lu Xia, Jian Wu, Yu-Chih Peng, Margaret Smith, Jack Chen, Carole A. Long, Justin Lack, Xin-zhuan Su   +10 more
doaj   +1 more source

Purification of Disassembled Capsid Protein by Hydroxyapatite Chromatography Enhances Virus‐Like Particle Recovery

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Virus‐like particles (VLPs) are a promising modality with extensive applications in prophylactic and therapeutic vaccine design. Human Papillomavirus (HPV) vaccines are one such example where VLP vaccine applications have led to the successful reduction in HPV‐associated diseases, such as cervical cancer.
Nicholas Samuelson, Nathaniel Parker, Shiyi Wang, Sara Daley, Aaron Cote, Michael A. Winters   +5 more
wiley   +1 more source

Viral vectors in malaria vaccine development [PDF]

Parasite Immunology, 2009
SummaryTraditional vaccine technologies have resulted in an impressive array of efficacious vaccines against a variety of infectious agents. However, several potentially deadly pathogens, including retroviruses and parasites, have proven less amenable to the application of traditional vaccine platforms, indicating the need for new approaches.
K J, Limbach, T L, Richie
openaire   +2 more sources

Therapeutic applications of collagenase (metalloproteases): A review

Asian Pacific Journal of Tropical Biomedicine, 2016
Non-invasive therapeutic methods have recently been used in medical sciences. Enzymes have shown high activity at very low concentrations in laboratories and pharmaceutical, enabling them to play crucial roles in different biological phenomena related to
Hamzeh Alipour, Abbasali Raz, Sedigheh Zakeri, Navid Dinparast Djadid   +3 more
doaj   +1 more source

Molecular characterization of RNase III protein of Asaia sp. for developing a robust RNAi-based paratransgensis tool to affect the sexual life-cycle of Plasmodium or Anopheles fitness

Parasites & Vectors, 2020
Background According to scientific recommendations, paratransgenesis is one of the solutions for improving the effectiveness of the Global Malaria Eradication Programme. In paratransgenesis, symbiont microorganisms are used for distorting or blocking the
Majid Asgari, Mahdokht Ilbeigikhamsehnejad, Elham Rismani, Navid Dinparast Djadid, Abbasali Raz   +4 more
doaj   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Nanophotonic Biosensors and the Paradigm of Trans‐Scale Autonomous Bio‐Integrated Diagnostics for Addressing Health Complexities

Electron, EarlyView.
Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary, Harsh Sable, Sonu Sonu, Lakshita Phor, Reddicherla Umapathi, Pradeep Bhadola   +5 more
wiley   +1 more source