Results 41 to 50 of about 38,153 (221)
Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley +1 more source
FEEDING AND RESTING PATTERN OF MALARIA VECTORS IN THREE COMMUNITIES FROM SOUTHEAST NIGERIA
The BioscientistAccurate knowledge of the feeding and resting time of malaria vectors is very crucial for malaria management, hence a 12-month longitudinal study was done to tackle the challenge of transmission of mosquito-borne diseases.
Emmanuel Okwudili Ogbuefi +3 more
doaj +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
World malaria report 2025: Growing biological threats, shrinking resources
Decoding Infection and TransmissionThe World Malaria Report 2025 documents operational progress while exposing systemic vulnerabilities that could reverse two decades of gains. Several biological threats are converging in Sub-Saharan Africa: artemisinin partial resistance, parasites ...
Lucien Platon, Feng Lu, Didier Ménard
doaj +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
A review on malaria eradication: what hope for Nigeria?
Journal of Applied Sciences and Environmental Management, 2016 Malaria and its transmitting vectors are household names. Malaria which helped Africa from the venomous fangs of colonialism has turned to be the bane of development in tropical countries including Nigeria.
E.C. Amadi
doaj +1 more source
SN Applied Sciences, 2021 Climate change/variability is a major driving factor among others that contribute to the spread of suitable malaria vectors’ geographical extent. The current study employed comparative spatial–temporal analysis using bioclimatic envelope modeling to ...
J. S. Kimuyu
doaj +1 more source
Malaria vectors in the world [PDF]
, 2021 Malaria is a severe disease caused by Plasmodium parasite species of which two - P. falciparum and P. vivax – are the most important for human. Despite the strong efforts made since the discovery of the aetiology, malaria is still a largely unresolved global public health problem, with 219 million cases in 90 countries estimated in 2017 (WHO Report ...
Romeo Bellini +2 more
openaire
Sickle Cell Disease: Historical Overview and Current Therapies
Prenatal Diagnosis, EarlyView.ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde +4 more
wiley +1 more source
Ecology of Malaria Vectors in an Endemic Area, Southeast of Iran
Journal of Arthropod-Borne Diseases, 2021 Background: Malaria has long been regarded as one of the most important public health issues in Iran. Although the country is now in the elimination phase, some endemic foci of malaria are still present in the southeastern areas of the country.
Hamideh Edalat +4 more
doaj +1 more source