Results 11 to 20 of about 151,333 (388)

MdWRKY126 modulates malate accumulation in apple fruit by regulating cytosolic malate dehydrogenase (MdMDH5)

Plant Physiology, 2022
The content of organic acids greatly influences the taste and storage life of fleshy fruit. Our current understanding of the molecular mechanism of organic acid accumulation in apple (Malus domestica) fruit focuses on the ALMT9/Ma1 (aluminum-activated ...
Lihua Zhang, Baiquan Ma, Changzhi Wang, Xingyu Chen, Yong‐Ling Ruan, Yangyang Yuan, Fengwang Ma, Mingjun Li   +7 more
openalex   +3 more sources

The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate

Nature Immunology, 2023
The malate shuttle is traditionally understood to maintain NAD^+/NADH balance between the cytosol and mitochondria. Whether the malate shuttle has additional functions is unclear.
Nina Weisshaar, Sicong Ma, Yanan Ming, Alaa Madi, Alessa Mieg, Marvin Hering, F. Zettl, Kerstin Mohr, Nora ten Bosch, Diana Stichling, Michael Buettner, Gernot Poschet, Glynis Klinke, Michael Schulz, Nina Kunze-Rohrbach, Carolin Kerber, I. M. Klein, Jingxia Wu, Xi Wang, Guoliang Cui   +19 more
semanticscholar   +1 more source

ABRE-BINDING FACTOR3-WRKY DNA-BINDING PROTEIN44 module promotes salinity-induced malate accumulation in pear.

Plant Physiology, 2023
Malate impacts fruit acidity and plays a vital role in stress tolerance. Malate accumulation is induced by salinity in various plants as a metabolite in coping with this stress.
A. Alabd, Haiyan Cheng, Mudassar Ahmad, Xinyue Wu, Lin Peng, Lu Wang, Shulin Yang, S. Bai, J. Ni, Yuanwen Teng   +9 more
semanticscholar   +1 more source

EAR APICAL DEGENERATION1 regulates maize ear development by maintaining malate supply for apical inflorescence.

The Plant Cell, 2022
Ear length (EL) is a key trait that contributes greatly to grain yield in maize (Zea mays). While numerous quantitative trait loci for EL have been identified, few causal genes have been studied in detail.
Yuanrong Pei, Ya-nan Deng, Huairen Zhang, Zhaogui Zhang, Jie Liu, Zhibin Chen, D. Cai, Kai Li, Yimo Du, Jie Zang, Peiyong Xin, Jinfang Chu, Yuhang Chen, Li Zhao, Juan Liu, Huabang Chen   +15 more
semanticscholar   +1 more source

Brassinosteroid signaling regulates phosphate starvation-induced malate secretion in plants.

Journal of Integrative Plant Biology, 2022
Inorganic phosphate (Pi) is often limited in soils due to precipitation with iron (Fe) and aluminum (Al). To scavenge heterogeneously distributed phosphorus (P) resources, plants have evolved a local Pi signaling pathway that induces malate secretion to ...
Tongtong Liu, S. Deng, Cheng Zhang, Xu Yang, Lei Shi, Fangsen Xu, Sheliang Wang, Chuang Wang   +7 more
semanticscholar   +1 more source

Genetic variation in the promoter of an R2R3-MYB transcription factor determines fruit malate content in apple (Malus domestica Borkh.).

Plant Physiology, 2021
Deciphering the mechanism of malate accumulation in apple (Malus domestica Borkh.) fruits can help to improve their flavor quality and enhance their benefits for human health.
Dongjie Jia, Pengchao Wu, Fei Shen, Wei Li, Xiaodong Zheng, Yongzhang Wang, Yongbing Yuan, Xinzhong Zhang, Zhenhai Han   +8 more
semanticscholar   +1 more source

Inborn disorders of the malate aspartate shuttle

Journal of Inherited Metabolic Disease, 2021
Over the last few years, various inborn disorders have been reported in the malate aspartate shuttle (MAS). The MAS consists of four metabolic enzymes and two transporters, one of them having two isoforms that are expressed in different tissues. Together
M. Broeks, C. V. van Karnebeek, R. Wanders, J. Jans, N. Verhoeven-Duif   +4 more
semanticscholar   +1 more source

The malate–aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2020
This article presents a personal and critical review of the history of the malate–aspartate shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a route for the oxidation of cytosolic NADH by the mitochondria in Ehrlich ...
P. Borst
semanticscholar   +1 more source

The versatility of plant organic acid metabolism in leaves is underpinned by mitochondrial malate–citrate exchange

The Plant Cell, 2021
Malate and citrate underpin the characteristic flexibility of central plant metabolism by linking mitochondrial respiratory metabolism with cytosolic biosynthetic pathways.
Chun-Pong Lee, Marlene Elsässer, Philippe Fuchs, R. Fenske, M. Schwarzländer, A. Millar   +5 more
semanticscholar   +1 more source

Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase

Nature Communications, 2020
Succinic acid (SA), a dicarboxylic acid of industrial importance, can be efficiently produced by metabolically engineered Mannheimia succiniciproducens.
J. Ahn, Hogyun Seo, W. Park, J. Seok, Jong An Lee, W. Kim, Gi Bae Kim, Kyung-Jin Kim, S. Lee   +8 more
semanticscholar   +1 more source