Structural mechanisms for cold‐adapted activity of phosphoenolpyruvate carboxykinase
Protein Science, Volume 34, Issue 11, November 2025.Abstract Temperature is a critical factor in enzyme function, as most enzymes are thermally activated. Across Earth's diverse environments (−20 to 120°C), enzymes have evolved to function optimally at their organism's growth temperature. Thermophilic enzymes must resist denaturation, while psychrophilic enzymes must maintain activity with limited ...
Matthew J. McLeod +3 more
wiley +1 more source
Length of course-based undergraduate research experiences (CURE) impacts student learning and attitudinal outcomes: A study of the Malate dehydrogenase CUREs Community (MCC). [PDF]
PLoS One, 2023 DeChenne-Peters SE +9 more
europepmc +1 more source
Complementary Muscle Metabolomics and Proteomics of Muscle in Cows With Post‐Calving Ketosis
Journal of Veterinary Internal Medicine, Volume 39, Issue 6, November/December 2025.ABSTRACT Background The muscle tissue of dairy cows is a site of β‐hydroxybutyrate (BHBA) metabolism. The mechanisms underlying the changes in proteins and metabolites in the muscle tissue of cows with ketosis remain unclear. Objectives To elucidate the metabolic and physiological molecular adaptation mechanisms in the muscle tissue of cows with ...
Tao Tang +8 more
wiley +1 more source
Protein Conformational Space at the Edge of Allostery: Turning a Nonallosteric Malate Dehydrogenase into an "Allosterized" Enzyme Using Evolution-Guided Punctual Mutations. [PDF]
Mol Biol Evol, 2022 Iorio A +4 more
europepmc +1 more source
Turnover of Malate‐Dehydrogenase Isozymes in Rabbit Liver and Heart [PDF]
, 1974 Gottfried Dölken +2 more
openalex +1 more source
Reproductive Barriers and Genomic Hotspots of Adaptation During Allopatric Species Divergence
Molecular Ecology, Volume 34, Issue 21, November 2025.ABSTRACT Theory predicts that in allopatric populations, genomic divergence and reproductive barriers may be driven by random genetic drift and thereby evolve slowly in large populations. However, local adaptation and divergence under selection may also play important roles, which remain poorly characterised.
Riddhi Deshmukh +4 more
wiley +1 more source
Tat-malate dehydrogenase fusion protein protects neurons from oxidative and ischemic damage by reduction of reactive oxygen species and modulation of glutathione redox system. [PDF]
Sci Rep, 2023 Kwon HJ +7 more
europepmc +1 more source
Disequilibrium in the malate dehydrogenase reaction in rat liver mitochondria in vivo [PDF]
, 1972 D. F. Heath, John C. Phillips
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Molecular Ecology, Volume 34, Issue 21, November 2025.ABSTRACT Alpine plants restricted to rocky habitats exhibit intraspecific diversification due to range fragmentation during Holocene warming, complicating predictions of their climate vulnerability. A lack of understanding of eco‐evolutionary mechanisms driving their response to climate change results in ineffective conservation efforts. To uncover the
Ewelina Klichowska +3 more
wiley +1 more source