Malate synthase contributes to the survival of Salmonella Typhimurium against nutrient and oxidative stress conditions [PDF]
Scientific Reports, 2022 To survive and replicate in the host, S. Typhimurium have evolved several metabolic pathways. The glyoxylate shunt is one such pathway that can utilize acetate for the synthesis of glucose and other biomolecules. This pathway is a bypass of the TCA cycle
Ratanti Sarkhel +5 more
doaj +3 more sources
Theranostic Application of a Novel G-Quadruplex-Forming DNA Aptamer Targeting Malate Synthase of Mycobacterium tuberculosis [PDF]
Molecular Therapy: Nucleic Acids, 2019 The successful management of tuberculosis (TB) requires efficient diagnosis and treatment. Further, the increasing prevalence of drug-resistant TB highlights the urgent need to develop novel inhibitors against both drug-susceptible and drug-resistant ...
Abhijeet Dhiman +13 more
doaj +3 more sources
Intermolecular interactions of the malate synthase of Paracoccidioides spp. [PDF]
BMC Microbiol, 2013 Abstract Background The fungus Paracoccidioides spp is the agent of paracoccidioidomycosis (PCM), a pulmonary mycosis acquired by the inhalation of fungal propagules. Paracoccidioides malate synthase (PbMLS) is important in the infectious process of Paracoccidioides spp because the transcript is up-regulated during ...
de Oliveira KM +8 more
europepmc +8 more sources
CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activity. [PDF]
Hum Mol Genet, 2014 CLYBL is a human mitochondrial enzyme of unknown function that is found in multiple eukaryotic taxa and conserved to bacteria. The protein is expressed in the mitochondria of all mammalian organs, with highest expression in brown fat and kidney. Approximately 5% of all humans harbor a premature stop polymorphism in CLYBL that has been associated with ...
Strittmatter L +5 more
europepmc +6 more sources
Evidence That Glyoxysomal Malate Synthase Is Segregated by the Endoplasmic Reticulum [PDF]
Plant Physiology, 1978 At the onset of castor bean (Ricinus communis) germination, 76% of the cellular malate synthase activity of the endosperm tissue was located in the microsomal fraction, with the remainder in the glyoxysomal fraction. During later developmental stages, when rapid malate synthase synthesis was occurring, an increasing proportion of the enzyme was ...
Janet M. Lord, Linda Bowden
semanticscholar +6 more sources
Biochemical characterization of malate synthase G of P. aeruginosa [PDF]
BMC Biochemistry, 2009 Abstract Background Malate synthase catalyzes the second step of the glyoxylate bypass, the condensation of acetyl coenzyme A and glyoxylate to form malate and coenzyme A (CoA). In several microorganisms, the glyoxylate bypass is of general importance to microbial pathogenesis.
Bart Roucourt +5 more
semanticscholar +6 more sources
Expression regulation of MALATE SYNTHASE involved in glyoxylate cycle during protocorm development in Phalaenopsis aphrodite (Orchidaceae). [PDF]
Sci Rep, 2020 Orchid (Orchidaceae) is one of the largest families in angiosperms and presents exceptional diversity in lifestyle. Their unique reproductive characteristics of orchid are attracted by scientist for centuries.
Wu WL +9 more
europepmc +2 more sources
The product complex of M. tuberculosis malate synthase revisited [PDF]
Protein Science, 2006 AbstractEnzymes of the glyoxylate shunt have been implicated as virulence factors in several pathogenic organisms, notably Mycobacterium tuberculosis and Candida albicans. Malate synthase has thus emerged as a promising target for design of anti‐microbial agents. For this effort, it is essential to have reliable models for enzyme:substrate complexes. A
David M. Anstrom, S. James Remington
semanticscholar +5 more sources
Spontaneous refolding of the large multidomain protein malate synthase G proceeds through misfolding traps. [PDF]
J Biol Chem, 2018 Most protein folding studies until now focus on single domain or truncated proteins. Although great insights in the folding of such systems has been accumulated, very little is known regarding the proteins containing multiple domains.
Kumar V, Chaudhuri TK.
europepmc +2 more sources
Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. [PDF]
J Biol Chem, 2016 Fragment screening and high throughput screening are complementary approaches that combine with structural biology to explore the binding capabilities of an active site.
Huang HL +4 more
europepmc +2 more sources