Malate synthase contributes to the survival of Salmonella Typhimurium against nutrient and oxidative stress conditions [PDF]
Scientific Reports, 2022 To survive and replicate in the host, S. Typhimurium have evolved several metabolic pathways. The glyoxylate shunt is one such pathway that can utilize acetate for the synthesis of glucose and other biomolecules. This pathway is a bypass of the TCA cycle
Ratanti Sarkhel +5 more
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Theranostic Application of a Novel G-Quadruplex-Forming DNA Aptamer Targeting Malate Synthase of Mycobacterium tuberculosis [PDF]
Molecular Therapy: Nucleic Acids, 2019 The successful management of tuberculosis (TB) requires efficient diagnosis and treatment. Further, the increasing prevalence of drug-resistant TB highlights the urgent need to develop novel inhibitors against both drug-susceptible and drug-resistant ...
Abhijeet Dhiman +13 more
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Expression regulation of MALATE SYNTHASE involved in glyoxylate cycle during protocorm development in Phalaenopsis aphrodite (Orchidaceae). [PDF]
Sci Rep, 2020 Orchid (Orchidaceae) is one of the largest families in angiosperms and presents exceptional diversity in lifestyle. Their unique reproductive characteristics of orchid are attracted by scientist for centuries.
Wu WL +9 more
europepmc +4 more sources
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis. [PDF]
Proc Natl Acad Sci U S A, 2017 Puckett S +9 more
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Intermolecular interactions of the malate synthase of Paracoccidioides spp. [PDF]
BMC Microbiol, 2013 BackgroundThe fungus Paracoccidioides spp is the agent of paracoccidioidomycosis (PCM), a pulmonary mycosis acquired by the inhalation of fungal propagules.
de Oliveira KM +8 more
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Spontaneous refolding of the large multidomain protein malate synthase G proceeds through misfolding traps. [PDF]
J Biol Chem, 2018 Most protein folding studies until now focus on single domain or truncated proteins. Although great insights in the folding of such systems has been accumulated, very little is known regarding the proteins containing multiple domains.
Kumar V, Chaudhuri TK.
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Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. [PDF]
J Biol Chem, 2016 Fragment screening and high throughput screening are complementary approaches that combine with structural biology to explore the binding capabilities of an active site.
Huang HL +4 more
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Ametryn and Clomazone Disrupt Mitochondrial Bioenergetics in Rat Liver: Evidence for Inhibition of Complexes I and II and ATP Synthase [PDF]
ToxicsAmetryn (AMT) and clomazone (CLZ) are commonly used herbicides frequently detected in food and water, raising concerns about potential health risks. This study investigated whether AMT and CLZ impair mitochondrial bioenergetics, a key mechanism linked to
Heberth Paulo dos Santos Silva +5 more
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Scientific Reports, 2021 Mitochondrial malate dehydrogenase (MDH)-citrate synthase (CS) multi-enzyme complex is a part of the Krebs tricarboxylic acid (TCA) cycle ‘metabolon’ which is enzyme machinery catalyzing sequential reactions without diffusion of reaction intermediates ...
Joy Omini +4 more
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Acta Societatis Botanicorum Poloniae, 2014 Centrifugation of a homogenate made from Pisum arvense L. roots in a sucrose density gradient enabled the separation of the plastid fraction from mitochondria and microsomes.
Genowefa Kubik-Dobosz, Grażyna Kłobus
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