Results 91 to 100 of about 324,763 (345)
The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]
, 2008 Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core +1 more source
Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]
, 2017 Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P +6 more
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BMC Structural Biology, 2011 BackgroundMalate synthase, one of the two enzymes unique to the glyoxylate cycle, is found in all three domains of life, and is crucial to the utilization of two-carbon compounds for net biosynthetic pathways such as gluconeogenesis.
C. Bracken +6 more
semanticscholar +1 more source
Ultracentrifugal and spectroscopic investigations on malate synthase from baker's yeast [PDF]
FEBS Letters, 1977 catalyzes the condensation of acetyl-CoA with glyoxylate to form malate [2]. The enzyme requires Mg2’ for activity [3]. It is specific for the substrate glyoxylate and does not show catalytic activity in the presence of the substrate analogues pyruvate, oxaloacetate, cY-ketoglutarate etc. 131.
Durchschlag, Helmut +4 more
openaire +2 more sources
Metabolites Modulate Malate Dehydrogenase‐Citrate Synthase Multienzyme Complex Formation
The FASEB Journal, 2021 Two tricarboxylic acid (TCA) cycle enzymes, citrate synthase (CS) and malate dehydrogenase (MDH), form a multi‐enzyme complex (MDH‐CS) that catalyzes two sequential reactions of the cycle. It is not known if this complex is static or dynamic and if it is dynamic, what are the factors that regulate its association/dissociation ...
Joy omini, Toshihiro Obata
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Animal Models and Experimental Medicine, EarlyView.An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen +12 more
wiley +1 more source
AMB Express, 2021 Reprogramming glycolysis for directing glycolytic metabolites to a specific metabolic pathway is expected to be useful for increasing microbial production of certain metabolites, such as amino acids, lipids or considerable secondary metabolites.
Hailong Chen +7 more
doaj +1 more source
A water-soluble form of porin from the mitochondrial outer membrane of Neurospora crassa [PDF]
, 1985 Mitochondrial porin, the outer membrane pore-forming protein, was isolated in the presence of detergents and converted into a water- soluble form. This water-soluble porin existed under nondenaturing conditions as a mixture of dimers and oligomers.
Benz, Roland +4 more
core
Biofuels, Bioproducts and Biorefining, EarlyView.Abstract This systematic review examines strategies for docosahexaenoic acid (DHA) production by thraustochytrids, focusing on cultivation techniques, fermentation technologies, and carbon/nitrogen optimization to increase productivity. Among 169 eligible articles, the 100 most productive studies (0.7–10.3 g DHA L−1 per day) were analyzed. Quantitative
Jhiovana Cristielly Carrera Silva da Costa +6 more
wiley +1 more source
Brain Region Specificity of Mitochondrial Biogenesis and Bioenergetics Response to Nrf2 Knockdown: A Comparison Among Hippocampus, Prefrontal Cortex and Amygdala of Male Rat Brain [PDF]
Brazilian Archives of Biology and Technology, 2017 Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) has been identified as the well-known coordinator of intracellular antioxidant defense system. Herein, we aimed to evaluate the effects of Nrf2 silencing on mitochondrial biogenesis markers peroxisome ...
Solmaz Khalifeh +5 more
doaj +2 more sources