Results 91 to 100 of about 321,356 (325)

Xylose Metabolism Perturbation in Yarrowia lipolytica for Efficient Succinic Acid Bioproduction from Lignocellulosic Biomass

Advanced Science, EarlyView.
This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong, Changyu Shang, Jinhong Gu, Huilin Tao, Xuemei Lu, Jin Hou, Zhiyong Cui, Qingsheng Qi   +7 more
wiley   +1 more source

Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. [PDF]

, 2011
Label-free LC-MS/MS-based shot-gun proteomics was used to quantify the differential protein synthesis and metabolite profiling in order to assess metabolic changes during the development of citrus fruits.
Blumwald, Eduardo, Boo, Kyung Hwan, Eigenheer, Richard A, Katz, Ehud, Kim, Ho Youn, Negre-Zakharov, Florence, Phinney, Brett S, Sadka, Avi, Shulaev, Vladimir   +8 more
core   +3 more sources

Succinic Acid Production by Engineered Mannheimia succiniciproducens and Its Use in Chemoenzymatic Poly(Butylene Succinate) Synthesis

Biotechnology and Bioengineering, EarlyView.
Succinic acid is produced by the fermentation of metabolically engineered Mannheimia succiniciproducens, purified, and used to synthesize poly(butylene succinate) using a two‐step process that involves the esterification of succinic acid and ethanol, followed by enzymatic transesterification of diethyl succinate and 1,4‐butanediol.
Ji Yeon Kim, Jong An Lee, Gi Bae Kim, Youngjoon Lee, Sang Yup Lee   +4 more
wiley   +1 more source

Interaction between Citrate Synthase and Malate Dehydrogenase [PDF]

Journal of Biological Chemistry, 1998
The interactions between pig heart citrate synthase and mitochondrial malate dehydrogenase or cytosolic malate dehydrogenase were studied using the frontal analysis method of gel filtration and by precipitation in polyethylene glycol. This method showed that an interaction between citrate synthase and mitochondrial malate dehydrogenase occurred but no ...
Igor Morgunov, Paul A. Srere
openaire   +3 more sources

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]

, 2017
Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P, Hodeib, Melissa, Karlan, Beth Y, Lunt, Sophia Y, Ogrodzinski, Martin P, Reue, Karen, Vergnes, Laurent   +6 more
core   +1 more source

Reaction Engineering of In Vitro Natural Product Biosynthesis: Challenges and Strategies

ChemBioChem, EarlyView.
The yield and turnover of in vitro natural product biosynthesis, and even its feasibility, are determined by intermolecular interactions. Reaction engineering allows to improve the performance of such complex biocatalytic systems. Natural products are widely used as pharmaceuticals and agrochemicals, or as active ingredients in food and cosmetics ...
Elsa Sánchez‐García, Stephan Lütz, Markus Nett   +2 more
wiley   +1 more source

Differentially expression analyses in fruit of cultivated and wild species of grape and peach

Scientific Reports, 2023
Through agronomic traits and sequencing data, the cultivated and wild varieties of grapes and peaches were analyzed and compared in terms of fruit size, fruit flavor, fruit resistance, and fruit color.
Weijian Huang, Meng Li, Huangwei Zhang, Juyou Wu, Jim M. Dunwell, Shaoling Zhang   +5 more
doaj   +1 more source

Mechanism study of alachlor biodegradation by Paecilomycesmarquandii with proteomic and metabolomic methods [PDF]

, 2015
Alachlor is an herbicide that is widely used worldwide to protect plant crops against broadleaf weedsand annual grasses. However, due to its endocrine-disrupting activity, its application had been bannedin the European Union.
Adrian Soboń, Agrawal, Altschul, Bregar, Böger, Carvalho, Charles, Chen, Chen, Chirnside, Coleman, Doyle, Fava, Feng, Ferreira de Oliveira, Ferrey, Fujii, Hou, Jerzy Długoński, Keum, Kroll, Li, Matsuzaki, Mirosława Słaba, Miura, Munoz, Perkins, Pothuluri, Rafał Szewczyk, Ringnér, Różalska, Salvachúa, Seo, Sette, Stamper, Szewczyk, Słaba, Słaba, Słaba, Tessier, Wei, Yang, Zhang   +42 more
core   +1 more source

Biological Conversion of Formate to Organic Compounds: Toward a Sustainable Formate Bioeconomy

Carbon Energy, EarlyView.
Formate bioconversion plays a crucial role in achieving renewable resource utilization and sustainable development. To tap its full potential, it is important to identify the most appropriate microbial hosts for incorporating formate into building blocks, design the most promising metabolic pathways for transmitting formate into central carbon ...
Jinyi Qian, Tiantian Chai, Chunlei Zhao, Xiulai Chen   +3 more
wiley   +1 more source

Increasing glycolysis by deletion of kcs1 and arg82 improved S-adenosyl-l-methionine production in Saccharomyces cerevisiae

AMB Express, 2021
Reprogramming glycolysis for directing glycolytic metabolites to a specific metabolic pathway is expected to be useful for increasing microbial production of certain metabolites, such as amino acids, lipids or considerable secondary metabolites.
Hailong Chen, Nianqing Zhu, Yan Wang, Xinxin Gao, Yuhe Song, Jia Zheng, Jiaping Peng, Xin Zhang   +7 more
doaj   +1 more source