Results 211 to 220 of about 7,875 (302)

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Menstrual cycle influence on skeletal muscle mitochondrial respiration in humans. [PDF]

Physiol Rep
Nelson WB, Pfeifer BS, Lovell AR, Marchant ED, Mitchell BV, Atkinson EL, Murphy TL, Poulsen SL, Baird JRK, Hancock CR, Hyldahl RD.   +10 more
europepmc   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

Spectroscopic Studies of Lanthanide(III) Complexes with L-Malic Acid in Binary Systems. [PDF]

Int J Mol Sci
Zabiszak M, Frymark J, Grajewski J, Jastrzab R.   +3 more
europepmc   +1 more source

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

Sex dimorphism and substrate dependency of liver mitochondrial bioenergetics and H₂O₂ production. [PDF]

Am J Physiol Gastrointest Liver Physiol
Dave DD, Taheri P, Boovarahan SR, Kim J, Cowley AW, Audi SH, Dash RK.   +6 more
europepmc   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

Malate targets pyruvate kinase M2 to promote colorectal cancer cell cycle arrest and tumor suppression. [PDF]

Mol Biomed
Zhao K, Zhang F, Qin Q, Zhang D, Yang F, Huang Y, Deng R, Jing H, Xiao W, Miao H, Shi R.   +10 more
europepmc   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

RIPK3 promotes ASIC1a-mediated fibroblast-like synoviocyte migration and invasion via malate shuttle-driven mitochondrial respiration in rheumatoid arthritis. [PDF]

Theranostics
Hu W, Wang K, Dong Y, Xu Y, Xing J, Zhu J, Ding J, Zhao Y, Xu Y, Cheng Y, Peng X, Zhou R, Hu W, Chen F.   +13 more
europepmc   +1 more source