Results 21 to 30 of about 7,875 (302)

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, EarlyView.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

Продуктивность и биохимический статус цыплят-бройлеров при использовании в их диете цитратов и малатов биометаллов [PDF]

, 2012
Приведены результаты влияния различных доз цитратов или малатов железа, марганца, цинка, меди и кобальта на рост и развитие цыплят-бройлеров, морфологический и биохимический состав крови, а так же химический состав их мышечной ...
Афанасьев, П. И., Горшков, Г. И., Кочеткова, Н. А., Шапошников, А. А., Шенцева, Е. А.   +4 more
core   +1 more source

Evaluation of di‐calcium malate, used as a novel food ingredient and as a source of calcium in foods for the general population, food supplements, total diet replacement for weight control and food for special medical purposes [PDF]

, 2018
The present scientific opinion deals with the evaluation of the safety of di‐calcium malate (DCM) proposed as a novel food ingredient and as a source of calcium for use in foods for the general population, food supplements, total diet replacement for ...
Aggett, Peter, Aguilar, Fernando, Crebelli, Riccardo, Dusemund, Birgit, Filipič, Metka, Frutos, Maria Jose, Galtier, Pierre, Gott, David, Gundert‐Remy, Ursula, Kuhnle, Gunter Georg, Lambré, Claude, Leblanc, Jean‐Charles, Lillegaard, Inger Therese, McArdle, Harry, Moldeus, Peter, Mortensen, Alicja, Oskarsson, Agneta, Pizzo, Fabiola, Rincon, Ana, Smeraldi, Camilla, Stankovic, Ivan, Tobback, Paul, Waalkens‐Berendsen, Ine, Woutersen, Rudolf Antonius, Wright, Matthew, Younes, Maged   +25 more
core   +4 more sources

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Antioxidant Properties of Pyrus communis and Pyrus pyrifolia Peel Extracts [PDF]

, 2020
With the rise of global health awareness by embracing a healthy lifestyle and natural product consumption, the search for natural antioxidant sources has invited more research performed especially in fruits as a whole product or in its components ...
Mardhatillah, Athina, Patricia, Vinda Maharani, Syaputri, Fauzia Ningrum, Tugon, Titian Daru Asmara   +3 more
core   +3 more sources

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

Advanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H. A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, Franz Schilling   +22 more
wiley   +1 more source

Malate utilization bySchizosaccharomyces pombe [PDF]

Biotechnology Letters, 1988
Malic acid degradation bySchizosaccharomyces pombe was studied in synthetic and natural media. Using different concentrations from 1 to 29 g/l, malic acid was degraded. Initial deacidification rate increased with initial malate concentration. During the stationnary phase,S.
Taillandier, Patricia, Riba, Jean-Pierre, Strehaiano, Pierre   +2 more
openaire   +3 more sources