Results 171 to 180 of about 1,727,460 (299)

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Phenotypic Florfenicol Resistance in floR‐Harbouring Flavobacterium psychrophilum Isolates (CC‐ST90): A Case Study From Danish Freshwater Rainbow Trout Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Monitoring antimicrobial resistance (AMR) in fish pathogens is essential for supporting sustainable aquaculture. In this study, susceptibility testing and genome sequencing were used to characterize the AMR profile of seven Flavobacterium psychrophilum originating from Danish rainbow trout farms (2019–2022).
Valentina L. Donati, Lone Madsen
wiley   +1 more source

Retrospective Identification of Lactococcus petauri Among Archived Isolates From Farmed Fish in Japan: Pathogenicity and Molecular Epidemiology

Journal of Fish Diseases, EarlyView.
ABSTRACT Lactococcosis, caused by Lactococcus garvieae, L. formosensis, and L. petauri, is an important bacterial disease of farmed fish worldwide. In Japan, L. petauri has not previously been reported as a cause of lactococcosis, although lactococcosis cases not attributable to either L. garvieae or L. formosensis have been recorded.
Tomoaki Yoshino, Tomokazu Takano, Yoshiko Shimahara, Yuta Matsuura, Shogo Harakawa, Yutaka Fukuda, Keisuke Yoshii, Yukitaka Sugihara, Kazuki Matsukura, Hiroki Koike, Hidehiro Kondo, Ikuo Hirono, Keiichiro Koiwai, Tomomasa Matsuyama   +13 more
wiley   +1 more source

Development of a Multiplex Polymerase Chain Reaction Assay for Differentiating Three Lactococcus Species Associated With Piscine Lactococcosis

Journal of Fish Diseases, EarlyView.
ABSTRACT Piscine lactococcosis is an important bacterial disease of farmed fish. The causative agents, Lactococcus garvieae, Lactococcus petauri and Lactococcus formosensis, are closely related, which complicates species‐level identification. We developed a conventional multiplex PCR assay targeting species‐specific genes identified by comparative ...
Tomoaki Yoshino, Tomokazu Takano, Hiroki Tanno, Yukihiro Nakagawa, Yuta Matsuura, Shogo Harakawa, Hidehiro Kondo, Ikuo Hirono, Keiichiro Koiwai, Tomomasa Matsuyama   +9 more
wiley   +1 more source

Development of a Multiplex Quantitative PCR Assay for Simultaneous Detection of Multiple Vibrio Species in Aquaculture Samples

Journal of Fish Diseases, EarlyView.
ABSTRACT Aquaculture associated Vibrio species are important bacterial pathogens causing significant economic losses in aquaculture and zoonotic infections in humans. Rapid and accurate detection of Vibrio species is therefore essential for diagnosis, surveillance and control.
İnci Başak Müştak, Hamit Kaan Müştak, Seyyide Sarıçam İnce, Doğukan Uğun, Görkem Cengiz, Gültekin Ünal, Ebru Torun, Muammer Göncüoğlu   +7 more
wiley   +1 more source

Evaluation of MALDI-TOF MS for identification of clinical filamentous fungi in a routine mycology laboratory. [PDF]

BMC Microbiol
Yazgan Z, Aygün G.
europepmc   +1 more source

Francisella orientalis in Aquacultured Tilapia (Oreochromis spp.): A Case Work‐Up of Diagnostics and Pathologic Findings in the North Central Region (USA)

Journal of Fish Diseases, EarlyView.
ABSTRACT Tilapia (Oreochromis spp.) is an increasingly popular aquacultured fish worldwide. While tilapia enjoy a ‘hardy‐fish’ reputation among fish farmers, they are susceptible to a variety of infectious diseases that can be difficult to recognize pondside and have similarities in their gross presentations. This report describes gross and microscopic
S. E. Edmonds, N. O. Hickey, C. Q. Reis, I. Kamonchai, M. J. Kebus, A. P. Pessier, T. B. Waltzek, K. R. Snekvik   +7 more
wiley   +1 more source